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atherosclerosis • vascular biology • arterial stiffness and vessel hemodynamics • hypertension • cardiovascular risk factors
My research focuses on the identification of early markers of vascular impairment and maintenance of vascular health. My objective is to integrate biomedical technology into an innovative cardiovascular research program aimed at unraveling the arteriosclerosis and atherosclerotic process and identifying early markers of severity and progression of vascular disease, as well as treatment efficacy. This program aims to improve upon the current paradigm of screening, investigating, monitoring, and assessing treatment of patients with vascular risk factors and/or established atherosclerotic disease through the assessment of: a) vascular function (e.g. arterial stiffness and hemodynamics), b) imaging (ultrasound and image analysis), c) blood markers (e.g. established and novel biomarkers, microRNAs), and d) the integration of fundamental methods (e.g. histology, immunohistochemistry, qRT-PCR, immunophenotyping). My view in research follows a mode "from microscope-through stethoscope-to telescope" allowing me to perform translational, patient-centered research.
Doonan RJ, Hafiane A, Lai C, Veinot JP, Genest J, Daskalopoulou SS. Cholesterol Efflux Capacity, Carotid Atherosclerosis, and Cerebrovascular Symptomatology. Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):921-926. PMID: 24558111.
Khan N, Daskalopoulou SS, Karp I, Eisenberg M, Pelletier R, Tsadok MA, Dasgupta K, Norris C, Pilote L for the GENESIS PRAXY Team. Sex Differences in Acute Coronary Syndrome Symptom Presentation in Young Patients. JAMA Intern Med. 2013 Nov 11;173(20):1863-1871. PMID: 24043208.
Daskalopoulou SS, Delaney JA, Filion KB, Brophy JM, Mayo NE, Suissa S. Discontinuation of Statin Therapy Following an Acute Myocardial Infarction: A Population-Based Study. Eur Heart J. 2008 Sep;29(17):2083-2091. PMID: 18664465.
Doonan RJ, Scheffler P, Yu A, Egiziano G, Mutter A, Bacon S, Carli F, Daskalopoulos ME, Daskalopoulou SS. Altered Arterial Stiffness and Subendocardial Viability Ratio in Young Healthy Light Smokers After Acute Exercise. PLoS One. 2011;6(10):e26151. PMID: 22028821.
Daskalopoulou SS, Cooke AB, Gomez Y-H, Mutter AF, Filippaios A, Mesfum E, Mantzoros C. Plasma Irisin Levels Progressively Increase in Response to Increasing Exercise Workloads in Young, Healthy, Active Subjects. Eur J Endocrinol. 2014 Sep;171(3):343-352. PMID: 24920292.