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atherosclerosis • vascular biology • arterial stiffness and vessel hemodynamics • hypertension • cardiovascular risk factors
My research focuses on the identification of early markers of vascular impairment and maintenance of vascular health. My objective is to integrate biomedical technology into an innovative cardiovascular research program aimed at unraveling the arteriosclerosis and atherosclerotic process and identifying early markers of severity and progression of vascular disease, as well as treatment efficacy. This program aims to improve upon the current paradigm of screening, investigating, monitoring, and assessing treatment of patients with vascular risk factors and/or established atherosclerotic disease through the assessment of vascular function (e.g., arterial stiffness and hemodynamics), imaging (ultrasound and image analysis), blood markers (e.g., established and novel biomarkers; microRNAs), and the integration of fundamental methods (e.g., histology, immunohistochemistry, qRT-PCR, immunophenotyping). My view in research follows a mode "from microscope—through stethoscope—to telescope," allowing me to perform translational, patient-centred research.
Gasbarrino K, Zheng H, Hafiane A, Veinot JP, Lai C, Daskalopoulou SS. Decreased Adiponectin-Mediated Signaling Through the AdipoR2 Pathway Is Associated With Carotid Plaque Instability. Stroke. 2017 Apr;48(4):915-924. doi: 10.1161/STROKEAHA.116.015145. Epub 2017 Mar 3. PMID: 28258256.
Gasbarrino K, Hafiane A, Zheng H, Daskalopoulou SS. Intensive Statin Therapy Compromises the Adiponectin-AdipoR Pathway in the Human Monocyte-Macrophage Lineage. Stroke. 2019 Dec;50(12):3609-3617. doi: 10.1161/STROKEAHA.119.026280. Epub 2019 Oct 25. PubMed PMID: 31648632.