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null David Labbé, PhD

Scientist, RI-MUHC, Glen site

Cancer Research Program

Centre for Translational Biology

Associate Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

prostate cancer • nutrition/diet • epigenetics • animal models • translational research

Research Focus

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, However, the molecular underpinnings of this association are poorly understood. My research program aims to understand the combination of key tumour genetic alterations together with the host characteristics required for diet to alter prostate cancer progression. This will allow the identification of new therapeutic targets and the elaboration of novel therapeutic approaches devised to treat prostate cancer patients at risk of progression to an aggressive, lethal disease. More specifically, my research focuses on the mechanisms and therapeutic targets related to epigenetic alterations, using murine and human cell lines, animal models (including genetically engineered mouse models) and human tissues.

Selected Publications

Click on Pubmed to see my current publications list

  • †Qiu, X.; †Boufaied, N.; Hallal, T.; Feit, A.; de Polo, A.; Luoma, AM.; Alahmadi, W.; Larocque, J.; Zadra, G.; Xie, Y.; Gu, S.; Tang, Q.; Zhang, Y.; Syamala, S.; Seo, J-H.; Bell, C.; O’Connor, E.; Liu, Y.; Schaeffer, EM.; Karnes, RJ.; Weinmann, S.; Davicioni, E.; Morrissey, C.; Cejas, P.; Ellis, L.; Loda, M.; Wucherpfennig, KW.; Pomerantz, MM.; Spratt, DE.; Corey, E.; Freedman, ML.; Liu, XS.; Brown, M.; ‡Long, HW.; ‡Labbé, DP. MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets, Nature Communications 13 (2022) 2559. †Contributed equally; ‡Co-corresponding. PMID: 35562350.

  • †Morel, KL.; †Sheahan, AV.; Burkhart, DL.; Baca, SC.; Boufaied, N.; Liu, Y.; Cañadas, I.; Roehle, K.; Heckler, M.; Calagua, C.; Ye, H.; Pantelidou, C.; Galbo, P.; Panja, S.; Mitrofanova, A.; Wilkinson, S.; Whitlock, NC.; Trostel, SY.; Hamid, AA.; Kibel, AS.; Barbie, DA.; Choudhury, AD.; Pomerantz, MM.; Sweeney, CJ.; Einstein, DJ.; Shapiro, GI.; Dougan, SK.; Sowalsky, AG.; He, HH.; Freedman, ML.; Balk, SP.; Loda, M.; Labbé, DP.; Olson, BM.; Ellis, L. EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer, Nature Cancer, 2(4) (2021) 444-456. †Contributed equally. PMID: 33899001.

  • de Polo, A.; Labbé, DP. Diet-dependent metabolic regulation of DNA double-strand break repair in cancer: More choices on the menu, Cancer Prevention Research (Phila), 14(4) (2021) 403-414. PMID: 33509805.

  • †Labbé, DP.; †Zadra, G.; Yang, M.; Reyes, JM.; Lin, CY.; Cacciatore, S.; Ebot, EM.; Creech, AL.; Giunchi, F.; Fiorentino, M.; Elfandy, H.; Syamala, S.; Karoly, ED.; Alshalalfa, M.; Erho, N.; Ross, A.; Schaeffer, EM.; Gibb, EA.; Takhar, M.; Den, RB.; Lehrer, J.; Karnes, RJ.; Freedland, SJ.; Davicioni, E.; Spratt, DE.; Ellis, L.; Jaffe, JD.; DʼAmico, AV.; Kantoff, PW.; Bradner, JE.; Mucci, LA.; Chavarro, JE.; ‡Loda, M.; ‡Brown, M. High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program, Nature Communications, 10(1) (2019) 4358. †Contributed equally; ‡Co-corresponding. PMID: 31554818.

  • Labbé, DP.; Sweeney, CJ.; Brown, M.; Galbo, P.; Rosario, S.; Wadosky, KM.; Ku, SY.; Sjöström, M.; Alshalalfa, M.; Erho, N.; Davicioni, E.; Karnes, RJ.; Schaeffer, EM.; Jenkins, RB.; Den, RB.; Ross, AE.; Bowden, M.; Huang, Y.; Gray, KP.; Feng, FY.; Spratt, DE.; Goodrich, DW.; Eng, KH.; Ellis, L. TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup, Clinical Cancer Research, 23(22) (2017) 7072-7083. PMID: 28899973.