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angle-left Bertrand Jean-Claude, M.Sc., PhD

Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine, McGill University

 

Keywords


Kinase inhibitors • anti-cancer drugs • pharmacokinetics • molecular modeling

Research Focus


My research focuses on the design and synthesis of new drug candidates designed to block multiple pathways in tumour cells.

Selected Publications


  • Qiu Q, Domarkas J, Banerjee R, Merayo N, Brahimi F, McNamee JP, Gibbs BF, Jean-Claude BJ. The combi-targeting concept: in vitro and in vivo fragmentation of a stable combi-nitrosourea engineered to interact with the epidermal growth factor receptor while remaining DNA reactive. Clin Cancer Res. 2007 Jan 1;13(1):331-40. PMID: 17200372.

  • Senhaji Mouhri Z, Goodfellow E, Kelley SP, Stein RS, Rogers RD, J Jean-Claude B. (15)N-, (13)C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene. Molecules. 2017 Jul 19;22(7). pii: E1183. doi: 10.3390/molecules22071183. PMID: 28753938.

  • Todorova MI, Larroque AL, Dauphin-Pierre S, Fang YQ, Jean-Claude BJ. Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species. Mol Cancer Ther. 2010 Apr;9(4):869-82. doi: 10.1158/1535-7163.MCT-09-0673. Epub 2010 Mar 30. PMID: 20354119.

  • Larroque-Lombard AL, Todorova M, Golabi N, Williams C, Jean-Claude BJ. Synthesis and uptake of fluorescence-labeled Combi-molecules by P-glycoprotein-proficient and -deficient uterine sarcoma cells MES-SA and MES-SA/DX5. J Med Chem. 2010 Mar 11;53(5):2104-13. doi: 10.1021/jm9016043. PMID: 20151639.

  • Rupp M, Mouhri ZS, Williams C, Jean-Claude BJ. Molecular analysis of the dual targeting of the epidermal growth factor receptor and the O(6)-methylguanine-DNA methyltransferase with a double arm hybrid molecule. Oncotarget. 2018 Oct 12;9(80):35041-35055. doi: 10.18632/oncotarget.25120. eCollection 2018 Oct 12. PMID: 30416678.