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angle-left George Thanassoulis, MD

Scientist, RI-MUHC , 5252 de Maisonneuve

Cardiovascular Health Across the Lifespan Program

Centre for Outcomes Research and Evaluation

Associate Professor, Department of Medicine, Faculty of Medicine, McGill University

Department of Medicine, Division of Cardiology, MUHC

 

Keywords


Genetics • genomics • cardiovascular disease • aortic stenosis • myocardial infarction • lipoprotein(a) • family history

Research Focus


My clinical interests are in cardiovascular prevention, dyslipidemia (specifically lipoprotein[a]) and premature coronary artery disease (CAD). I currently run the MUHC Family Heart Clinic for patients with premature CAD and their families with the goal of optimizing their preventive care. My research focuses on the genetics of aortic valve stenosis. I am the leader of an international consortium that investigates the role of genomic variation in aortic valve stenosis. I also work on developing new approaches to optimize cardiovascular prevention in young individuals.

Selected Publications


Click on Pubmed to see my current publications list

  • Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O’Donnell CJ, Rotter JI, Tsai MY, Post W, Clarke R, Söderberg S, Bossé, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G. Genetic Variation at FADS1/2 locus, Polyunsaturated Fatty Acids and Aortic Stenosis. (In press).

  • HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O'Donnell CJ. Nat Genet. 2019 Nov;51(11):1580-1587. doi: 10.1038/s41588-019-0514-8. Epub 2019 Oct 28.

  • A Long-term Benefit Approach vs Standard Risk-Based Approaches for Statin Eligibility in Primary Prevention. Thanassoulis G, Sniderman AD, Pencina MJ. JAMA Cardiol. 2018 Nov 1;3(11):1090-1095. doi: 10.1001/jamacardio.2018.3476.

  • Association of LPA Variants With Aortic Stenosis: A Large-Scale Study Using Diagnostic and Procedural Codes From Electronic Health Records. Chen HY, Dufresne L, Burr H, Ambikkumar A, Yasui N, Luk K, Ranatunga DK, Whitmer RA, Lathrop M, Engert JC, Thanassoulis G. JAMA Cardiol. 2018 Jan 1;3(1):18-23. doi: 10.1001/jamacardio.2017.4266. Erratum in: JAMA Cardiol. 2018 Oct 1;3(10):1026.

  • Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. Afshar M, Luk K, Do R, Dufresne L, Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q, Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich SS, Engert JC, Gudnason V, O'Donnell CJ, Post WS, Thanassoulis G; CHARGE Extracoronary Calcium Working Group. J Am Coll Cardiol. 2017 Jun 20;69(24):2941-2948. doi: 10.1016/j.jacc.2017.04.051.