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endothelial cells • angiogenesis • skeletal muscle atrophy
My research focuses on two areas of research. First, in the field of vascular biology, my main interest in elucidating signaling mechanisms and biological actions of angiopoietins and vascular endothelial cell growth factor. My interest in this area focuses on the role of microRNAs and various transcription factors in mediating the pro-angiogenic and anti-inflammatory effects of angiopoietins in the vascular system. Second,in the field of skeletal muscle biology, I focus on elucidating the molecular mechanisms that regulate skeletal muscle mass, mitochondrial homeostasis and contractile function including the proteasome, caspases and autophagy. I am particularly interested in the functional importance and the specific contribution of principle proteolytic pathways such as the proteasome and autophagy in regulating skeletal muscle function in various diseases that are associated with significant skeletal muscle contractile dysfunction and atrophy including severe sepsis, intensive-care acquired muscle dysfunction, prolonged mechanical ventilation and in patients with emphysema.
Angiopoietin-1 enhances skeletal muscle regeneration in mice. Mofarrahi M, McClung JM, Kontos CD et al. Am. J. Physiol. Regul. Integ. Comp. Physiol.308(7):R576-89, 2015 PMID: 25608750.
Autophagy in locomtor muscles of patients with chronic obstructive pulmonary disease. Guo Y, Gosker HR, Schol AM et al. Am J. Resp. Crit. Care Med. 188(11):1313-20, 2013 PMID: 24228729.
Autophagy in skeletal muscles in sepsis. Mofarrahi M, Sigala I, Guo Y et al. Plose One 7(10):e47265, 2012 PMID: 23056618.