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angle-left Jacques Genest, MD

Senior Scientist, RI-MUHC , Glen site

Cardiovascular Health Across the Lifespan Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine, McGill University

Department of Medicine, Division of Cardiology, MUHC



lipoproteins • high-density lipoprotein (HDL) • familial hypercholesterolemia • genetics • ABCA1

Research Focus

My research focuses on understanding the genetic basis of early atherosclerosis (hardening of the arteries leading to heart attacks and strokes).

Selected Publications

Click on Pubmed to see my current publications list

  • Iatan I, Choi H, Ruel I, Linga-Reddy P, Hyunsuk K, Abu Odeh M, Weissglas-Volkov D, Nikkola E, Awan Z, Lee J, Aqeilan R, Pajukanta P, Aldaz M, Genest J. The WW Domain-containing Oxidoreductase (Wwox) Gene Modulates HDL Metabolism and Lipoprotein Gene Expression. Circ Cardiovasc Genet 2014;7:491-514 PMID: 24871327.

  • Awan Z, Denis M, Roubtsova A, Awan A, Gram H, Seidah N, Genest J. Prevention of Vascular Calcification by Interleukin-1b Inhibition in a Mouse Model. Accepted Angiology Mar 2015.

  • Hafiane A, Bielicki J, Johansson J, Genest J. HDL Mimetic Peptide ATI-5261 Induce ABCA1 Oligomerization, disrupt plasma membrane microdomains and Generate Nascent HDL-Like Lipoproteins [*] [CIHR MOP 15042; HSCF BBA Lipids 2014;1842;1498-512.

  • Genest J, Hegele RA, Bergeron J, Brophy J, Carpentier A, Couture P, Davignon J, Dufour R, Frohlich J, Gaudet D, Gupta M, Krisnamoorty P, Mancini JMcCrindle B, Raggi P, Ruel I, St-Pierre J. Canadian Cardiovascular Society Position Statement on Familial Hypercholesterolemia. Can J Cardiol 2014;30:1471-1481 PMID: 25448461.

  • Choi HY, Ruel I, Malina A, Garrod DR, Oda MN, Green KJ, Genest J. Membrane micro-domains and HDL formation: A novel apolipoprotein A-I binding protein desmocollin 1 inhibits HDL biogenesis.