null Matthew Cheng, MD

Junior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University



lethal infectious diseases • opportunistic infections • sepsis • bacteremia

Research Focus

My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.

Selected Publications

Click on Pubmed to see my current publications list

  • Cheng MP, Stenstrom R, Paquette K, Stabler SN, Akhter M, Davidson AC, Gavric M, Lawandi A, Jinah R, Saeed Z, Demir K, Huang K, Mahpour A, Shamatutu C, Caya C, Troquet JM, Clark G, Yansouni CP, Sweet D; FABLED Investigators. Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study. Ann Intern Med. 2019 Oct 15;171(8):547-554. doi: 10.7326/M19-1696. Epub 2019 Sep 17. PMID: 31525774.

  • Cheng MP, Lawandi A, Butler-Laporte G, De l'Etoile-Morel S, Paquette K, Lee TC. Adjunctive Daptomycin in the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Randomized Controlled Trial. Clin Infect Dis. 2020 Jul 15:ciaa1000. doi: 10.1093/cid/ciaa1000. Epub ahead of print. PMID: 32667982.

  • Cheng MP, Papenburg J, Desjardins M, Kanjilal S, Quach C, Libman M, Dittrich S, Yansouni CP. Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus 2: A Narrative Review. Ann Intern Med. 2020 Jun 2;172(11):726-734. doi: 10.7326/M20-1301. Epub 2020 Apr 13. PMID: 32282894.

  • Cheng AP, Cheng MP, Gu W, Lenz JS, Hsu E, Schurr E, Bourque G, Bourgey M, Ritz J, Marty FM, Chiu CY, Vinh DC, De Vlaminck I. Cell-Free DNA Tissues-of-Origin by Methylation Profiling Reveals Significant Cell, Tissue and Organ-Specific injury related to COVID-19 Severity. Med (N Y). 2021 Jan 16. doi: 10.1016/j.medj.2021.01.001. Epub ahead of print. PMID: 33521749.

  • Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, Skipper CP, Nascene AA, Nicol MR, Abassi M, Engen NW, Cheng MP, LaBar D, Lother SA, MacKenzie LJ, Drobot G, Marten N, Zarychanski R, Kelly LE, Schwartz IS, McDonald EG, Rajasingham R, Lee TC, Hullsiek KH. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19. N Engl J Med. 2020 Aug 6;383(6):517-525. doi: 10.1056/NEJMoa2016638. Epub 2020 Jun 3. PMID: 32492293.