null Jun-Li Liu, PhD
CCN5/WISP2 • pancreatic islets • growth and development • transgenic mice • knockout mice • insulin-like growth factor • Reg family proteins
My research focuses on exploring novel growth factors that can be used to expand or preserve the islet beta cells, which make the key hormone insulin, against onset of diabetes mellitus. Our current focus is on a family of proteins normally produced in the pancreas, some of which have been shown to be effective in rodent models of the disease.
Zhang H, Corredor ALG, Messina-Pacheco J, Li Q, Zogopoulos G, Kaddour N, Wang Y, Shi B-y, Gregorieff A, Liu J-l, Gao Z-h. REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway. Communications Biology. 2021; 4(1):688.
Liu JL, Segovia I, Yuan XL, Gao ZH. Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic beta-Cell Growth and Insulin Secretion. Int J Mol Sci 2020; 21:910 PMC7037182.
Yu L, Li X, Zhang Z, Du P, Liu JL, Li Y, Yin T, Yu W, Sun H, Wang M, Luo C. Dimorphic autoantigenic and protective effects of Reg2 peptide in the treatment of diabetic beta-cell loss. Diabetes Obes Metab 2019; 21:1209-1222. PMID: 30690849.
Liu JL, Gao ZH. Does GLP-1 suppress hepatocyte glucose production directly, via fibroblast growth factor 21? EBioMedicine 2019; 41:5-6. PMID: 30876763.
Li Q, Li B, Miao X, Ramgattie C, Gao ZH, Liu JL. Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity. Endocrinology 2017; 158:1634-1644. PMID: 28009527.