growth and development • transgenic mice • Cre/loxP system • insulin-like growth factor • Reg family proteins
My research focuses on exploring novel growth factors that can be used to expand or preserve the islet beta cells, which make the key hormone insulin, against onset of diabetes mellitus. Our current focus is on a family of proteins normally produced in the pancreas, some of which have been shown to be effective in rodent models of the disease.
JL Liu, ZH Gao. Does GLP-1 suppress hepatocyte glucose production directly, via fibroblast growth factor 21? EBioMedicine 2019; 41: 5-6. PMID: 30876763.
*Q Li, B Li, X Miao, C Ramgattie, ZH Gao, JL Liu. Reg2 expression is required for pancreatic islet compensation in response to aging and high fat diet-induced obesity. Endocrinology 2017; 158: 1634-1644. PMID: 28009527.
*Q Li, H Wang, G Zogopoulos, Q Shao, K Dong, F Lv, K Nwilati, XY Gui, A Cuggia, *JL Liu, ZH Gao. Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma. Oncotarget 2016; 7: 77838-77853 (Co-corresponding author). PMID: 27788482.