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growth and development • transgenic mice • Cre/loxP system • insulin-like growth factor • Reg family proteins
My research focuses on exploring novel growth factors that can be used to expand or preserve the islet beta cells, which make the key hormone insulin, against onset of diabetes mellitus. Our current focus is on a family of proteins normally produced in the pancreas, some of which have been shown to be effective in rodent models of the disease.
Liu JL, Segovia I, Yuan XL, Gao ZH. Controversial Roles of Gut Microbiota-Derived Short-Chain Fatty Acids (SCFAs) on Pancreatic beta-Cell Growth and Insulin Secretion. Int J Mol Sci 2020; 21:910 PMC7037182.
Yu L, Li X, Zhang Z, Du P, Liu JL, Li Y, Yin T, Yu W, Sun H, Wang M, Luo C. Dimorphic autoantigenic and protective effects of Reg2 peptide in the treatment of diabetic beta-cell loss. Diabetes Obes Metab 2019; 21:1209-1222. PMID: 30690849.
Liu JL, Gao ZH. Does GLP-1 suppress hepatocyte glucose production directly, via fibroblast growth factor 21? EBioMedicine 2019; 41:5-6. PMID: 30876763.
Li Q, Li B, Miao X, Ramgattie C, Gao ZH, Liu JL. Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity. Endocrinology 2017; 158:1634-1644. PMID: 28009527.
Li Q, Wang H, Zogopoulos G, Shao Q, Dong K, Lv F, Nwilati K, Gui XY, Cuggia A, Liu JL, Gao ZH. Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma. Oncotarget 2016; 7:77838-77853. PMID: 27788482.