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fungal infection • pneumonia • sepsis • forward genetic analysis • innate immunity
My research focuses on identifying and characterizing molecules that are essential for protection against progressive respiratory and/or systemic infection (pneumonia and sepsis) using mouse models that accurately represent human disease. We use several genetic approaches to identify host susceptibility factors and combine this with detailed immunological analysis of the defective genes and their respective pathways. We are also developing protocols to study these molecules in critically ill patients with severe infections. A comprehensive understanding of the molecular foundation of protective immunity will lead to the development of new prevention and treatment strategies against the relentless microbial threat to human health.
Flaczyk, A., Duerr, C.U., Shourian, M., Lafferty, E., Fritz, J.H., Qureshi, S.T. IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans. Journal of Immunology 2013 Sep 1;191(5):2503-13. doi: 10.4049/jimmunol.1300426. Epub 2013 Jul 26. PMID: 23894196.
Carroll, S.F., Lafferty, E.I., Flaczyk, A., Fujiwara, M., Homer, R., Morgan, K., Loredo Osti J.C., Qureshi, S.T. Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9 Infection and Immunity 2012 Dec;80(12):4167-76. doi: 10.1128/IAI.00417-12. Epub 2012 Sep 17. PMID: 22988020.
Fielhaber, J.A., Carroll, S.F., Dydensborg, A.B., Shourian, M., Triantafillopoulos, A., Harrel, S., Hussain, S.N., Bouchard, M., Qureshi, S.T., Kristof, A.S. Inhibition of Mammalian Target of Rapamycin Augments Lipopolysaccharide-induced Lung Injury and Apoptosis J Immunol. 2012 May 1;188(9):4535-42. Epub 2012 Mar 26 2012 PMID: 22450807.
Guillot, L., Carroll, S.F., Homer, R.J., and Qureshi, S.T. (2008) Enhanced pulmonary innate immune responsiveness to Cryptococcus neoformans is associated with resistance to progressive infection Infect Immun 76(10):4745-56 PMID: 18678664.
Carroll, S.F., Guillot, L., Loredo-Osti, J.C., Morgan, K, and Qureshi, S.T. (2008) Sex differences in the genetic architecture of Cryptococcus neoformans pneumonia Genes Immun 9(6):536-45 PMID: 18563168.