nutrition • metabolism • insulin resistance • stable isotopes • clinical and translational research
My research focuses on the alterations in protein metabolism that lead to muscle loss. This occurs under certain conditions when muscle cells are resistant to the anabolic effect of insulin, such as in obesity and type 2 diabetes, and also in aging and cancer. Muscle loss has debilitating consequences, as it reduces physical function, mobility, autonomy, and tolerance to cancer treatment. My work involves the use of stable isotope tracer methodology and mass spectrometry with mathematical modeling to quantify metabolic fluxes in healthy subjects and ill patients. This approach allows us to measure the rates at which proteins are being synthesized or degraded and how much glucose is being produced or utilized, under determined conditions. My main research objective is to better understand the role of diet, and particularly dietary proteins and their constituents, amino acids, in counteracting muscle loss while optimizing nutritional and metabolic status.
Chevalier S, Burgos SA, Morais JA, Gougeon R, Bassil M, Lamarche M, Marliss EB. Protein and glucose metabolic responses to hyperinsulinemia, hyperglycemia, and hyperaminoacidemia in obese men.Obesity 23 (2); 351-8, 2015. PMID: 25452199.
Chevalier S, Winter A. Do patients with advanced cancer have any potential for protein anabolism in response to amino acid therapy? Curr Opin Clin Nutr Metab Care. 17(3):213-8, 2014. PMID: 24572834.
Winter A, MacAdams J, Chevalier S. Normal protein anabolic response to hyperaminoacidemia in insulin-resistant patients with lung cancer cachexia. Clin Nutr 31: 765-773, 2012. PMID: 22647419.
Bassil M, Burgos SA, Marliss EB, Morais JA, Chevalier S and Gougeon R. Hyperaminoacidemia at postprandial levels does not modulate glucose metabolism in type 2 diabetes mellitus. Diabetologia 54(7): 1810-8, 2011. PMID: 21437771.
Chevalier S, Goulet E, Burgos SA, Wykes LJ, Morais JA. Protein anabolic responses to fed steady-state in healthy aging. J Gerontol Biol Med Sci 66 (6); 681-8, 2011. PMID: 21436253.