null Stéphanie Chevalier, RD, PhD
nutrition • metabolism • sarcopenia • aging • lung cancer • surgical prehabilitation
My research focuses on alterations in protein metabolism leading to muscle loss in older persons, and in those living with type 2 diabetes or having cancer. Muscle loss has debilitating consequences, as it reduces physical function, mobility, autonomy, and tolerance to cancer surgery and treatment. My work involves the use of stable isotope tracer methodology to quantify skeletal muscle mass and the synthesis and degradation of muscle protein in healthy subjects and ill patients. My main research objective is to better understand the role of diet, and particularly dietary proteins and their constituents, amino acids, in counteracting muscle loss while optimizing nutritional and metabolic status. This research is conducted through randomized clinical trials and analysis of observational cohort studies. Current projects include a multimodal intervention to improve physical function and recovery after surgery in patients with lung cancer.
A-J Tessier, SS Wing, E Rahme, JA Morais, S Chevalier. Association of low muscle mass with cognitive function during a 3-year follow-up among adults aged 65 to 86 years in the Canadian Longitudinal Study on Aging. JAMA Network Open 2022;5(7): e2219926. Doi:10.1001/jamanetworkopen.2022.19926. PMID: 35796211.
A-J Tessier, J Lévy-Ndejuru, A Moyen, M Lawson, M Lamarche, JA Morais, A Bhullar, F Andriamampionona, VC Mazurak, S Chevalier. A 16-week randomized controlled trial of a fish oil and whey protein-derived supplement to improve physical performance in older adults losing autonomy – a pilot study. PlosOne 2021 Aug 23, 16(8): e0256386. Doi: 10.1371/journal.pone.0256386. PMID: 34424934.
C Lawson, V Ferreira, F Carli, S Chevalier. Effects of multimodal prehabilitation on muscle size, myosteatosis, and dietary intake of surgical patients with lung cancer – a randomized feasibility study. Appl Physiol Nutr Metab 2021 Jul 15 46(11); 1407-1416. Doi: 10.1139/apnm-2021-0249. PMID: 34265218.
V Ferreira V, C Lawson, F Carli, C Scheede-Bergdahl, S Chevalier. Feasibility of a novel mixed-nutrient supplement in a multimodal prehabilitation intervention for lung cancer patients awaiting surgery: a randomized controlled pilot trial. Int J Surgery 2021 93:106079. Epub Aug 28; 93:106079. Doi: 10.1016/j.ijsu.2021.106079. PMID: 34464752.
A-J Tessier, SS Wing, E Rahme, JA Morais, S Chevalier. Physical function-derived cut-points for the diagnosis of sarcopenia and dynapenia in the Canadian Longitudinal Study on Aging. J Cachexia Sarc Muscle 10(5): 985-99, 2019. Epub 2019 July 15. https://doi.org/10.1002/jcsm.12462. PMID: 31307126.