null Louise Pilote, MD, MPH, PhD
comparative effectivenesse • sex differences in cardiovascular diseases • outcomes research • cardiovascular epidemiology • pharmacoepidemiology
As an internationally recognized sex and gender scientist, leader in cardiovascular research and pioneer in comparative effectiveness research using Big Data, I have developed novel methodologies for measuring gender to understand the association between sex, social determinants, and cardiovascular diseases. The gender index developed by my team measures a comprehensive group of gender-related factors and offers a novel means to explore the relationship between sex, gender, and health outcomes. This work highlights that both biology (sex) and society (gender) influence presentation, process of care and health outcome in distinct, yet interrelated, ways. I currently lead the Gender Outcomes International Group to Further Well-being Development (GOING-FWD), a data science and personalized medicine project. This consortium of thirty investigators from five countries aims to maximize risk prediction through the integration of sex and gender analysis in research using thirty cohorts of 30 million patients with chronic diseases.
I am an authority on the use of administrative data bases (“Secondary Big Data”), large prospective clinical registries, and the use of innovative study designs and data analyses. A leader in comparative effectiveness studies, I identified sex differences in the safety and efficacy of cardiac drugs and devices and uncovered clinical equipoise in anticoagulation for atrial fibrillation in dialysis patients.
I have applied a sex and gender lens to bridge basic to epidemiological sciences and uncovered an association between hypertensive disorders of pregnancy and cognitive decline. I currently lead a study to evaluate novel cardiac imaging to diagnose coronary microvascular dysfunction, a pathogenesis of coronary disease most prevalent in women.
Tadiri CP, Raparelli V, Abrahamowicz M, Kautsky-Willer A, Kublickiene K, Herrero MT, Norris CM, Pilote L. Methods for prospectively incorporating gender into health sciences research. Journal of Clinical Epidemiology. 2021 January; 129:191-197. PMID: 32980428.
Muhammad AW, Raparelli V, Pilote L, Daskalapoulou SS. Drs Pilote and Daskalopoulou contributed as co-senior authors. Blood pressure variability in normotensive perimenopausal women: Non-dipping status, maximum blood pressure and arterial stiffness. International Journal of Cardiology. Available online 16 October 2020. PMID: 33075385.
Raparelli V, Elharram M, Moura CS, Abrahamowicz M, Bernatsky S, Behlouli H, Pilote L. Sex differences in effectiveness of newer glucose-lowering drugs added to metformin in type-2 diabetes. JAHA. 2020 Jan;9(1):e012940. PMID: 31902326.
Kaur A, Mackin ST, Schlosser K, Wong FL, Elharram M, Delles C, Stewart DJ, Dayan N, Landry T, Pilote L. Systematic Review of MicroRNA Biomarkers in Acute Coronary Syndrome and Stable Coronary Artery Disease. Cardiovasc Res. 2019 Nov 29. pii: cvz302. (Editor’s choice, May 2020). PMID: 31782762.