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TGF&beta • Smad signaling • tumor suppression • breast cancer metastasis • melanoma research • cell growth arrest • apoptosis • cell immortalization • cell migration • cell invasion
My research focuses on investigating the role and mechanism of action of the transforming growth factor-&beta (TGF&beta) in the regulation of tumor formation and cancer progression, with a long term goal of developing novel therapies against metastatic cancer. The various research projects that I developed in my laboratory are based on the dual role of this growth factor in cancer. On one hand TGFB exerts tumor suppressive effects in normal cells and in early carcinomas whereas in advanced cancer TGF&beta has pro-migratory and pro-invasive functions. With this information, we have developed two lines of research. The first is defining the tumor suppressive role of TGF&beta and how this growth factor inhibits cell proliferation, induces apoptosis, and prevents cell immortalization in normal cells and early carcinomas. The second is defining the pro-metastatic effect of this cytokine in invasive cancers, focusing on breast cancer, with the goal of designing novel anti-TGF&beta signaling therapies against cancer.
Ghozlan M, Boudreault J, Haiub H, Wang N, Lebrun JJ (2019) The Axin Upregulated Protein 1 (AXUD1) suppresses tumor formation and metastasis downstream of TGFβ/Smad3 signaling in human cutaneous melanoma (2019) Mol Oncology (in press).
Tian J, Al Raffa F, Dai M, Moamer A, Khandag B, Bakdounes K, Ali S, Jean-Claude B, Lebrun JJ. (2018). Dasatinib Sensitizes Triple Negative Breast Cancer Cells to Chemotherapy by Targeting Breast Cancer Stem Cells. British Journal of Cancer. Br J Cancer. 2018 Nov 28.
Tian J, AlOdaini A, Wang Y, Dai M, Ali S, Lebrun JJ. (2018). KiSS1 gene as a novel mediator of TGFβ pro-invasive effects in triple negative breast cancer. Cell Signal. 2018 Jan;42:1-10.
Hachim MY, Hachim IY, Dai M, Ali S, Lebrun JJ. (2018) Differential expression of TGFβ isoforms in breast cancer highlights different roles during breast cancer progression. Tumor Biology Jan;40(1):1010428317748254.
Hachim IY, Villatoro M, Canaff L, Hachim M, Boudreault J, Haiub H, Ali S, Lebrun JJ. (2017). Transforming Growth Factor-beta Regulation Of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration. Nature Scientific Reports. 2017 Nov 3;7(1):14976.