traumatic brain injury • concussion • blindsight
My research focuses on motor recovery in stroke and the neural substrates of residual vision in the blind visual field following hemispherectomy, using functional magnetic resonance imaging (fMRI). I have also used fMRI to help diagnose traumatic brain injury (TBI) in soldiers, athletes, motor vehicle accident victims and children as well as to assess recovery. With my research team, we have reported that there are abnormal activation patterns following TBI and that fMRI can serve as an objective method to assess the severity of the injury and subsequent recovery. Recently, I have used repetitive transcranial magnetic stimulation to treat dysfunctional brain activity and post concussive symptoms, including depression and cognitive impairment, following mild TBI. I will also begin to investigate stimulation of the tongue as a new neuromodulation treatment approach, in combination with intensive physical therapy, to improve gait and balance following mild to moderate TBI.
Ptito A, Chen JK*, Johnston KM. (2007) Contributions of fMRI to sport concussion evaluation. NeuroRehabilitation. 22(3):217-227. PMID: 17917172.
Ptito A, Leh SE. Neural substrates of blindsight after hemispherectomy (2007) Neuroscientist. 2007 Oct;13(5):506-18. PMID: 17901259.
Gosselin N**, Bottari C*, Chen JK, Huntgeburth SC**, De Beaumont L, Petrides M, Cheung B, Ptito A. (2012) Evaluating the cognitive consequences of mild traumatic brain injury or concussion using electrophysiology, Neurosurgical Focus Dec;33(6):E7: 1-7. PMID: 23199430.
Koski L, Kolivakis T, Yu C, Chen JK, Delaney S, Ptito A.. (2015). Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury. Journal of Neurotrauma. 32(1): 38-44. PMID: 24955920.
Keightley, ML, Saluja, RJ**, Chen, J-K, Gagnon, I, Leonard, G, Petrides, M, Ptito, A (2014) A Functional Magnetic Resonance Imaging Study of Working Memory in Youth after Sports-Related Concussion: Is It Still Working? Journal of Neurotrauma. 31 (5): 437-51. PMID: 24070614.