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null Ana Copaescu, MD, PhD

Associate Investigator, RI-MUHC , Montreal General Hospital

Infectious Diseases and Immunity in Global Health Program

 

Keywords


immune-mediated adverse drug reactions • severe cutaneous adverse reaction • point-of-care solutions • risk stratification tools • in vivo diagnostic tools • ex vivo diagnostic tools • clinical trials

Research Focus


My research focuses on drug allergy−related pathologies, including their clinical identification, diagnostic methods and management. The ongoing clinical and translational research projects aim to improve precision diagnosis, including mechanisms to remove drug allergy labels and develop diagnostic tools. Additionally, I aim to advance our understanding of the complex, severe, delayed drug reactions associated with significant acute and long-term morbidity and mortality. These developments allow me to be part of a network of international collaborators, an excellent platform for exchanging and developing new projects. Addressing the significant health issue of immune-mediated drug allergy will lead to high-level research output that will translate into improvement in healthcare, locally and internationally.

I maintain strong collaborations as an honorary fellow in the Department of Infectious Diseases, University of Melbourne, and doctoral candidate in the Centre for Antibiotic Allergy and Research, Austin Health, also in Melbourne, Australia.

Selected Publications


Click on Pubmed to see my current publications list

  • Copaescu A, Mouhtouris E, Vogrin S, James F, Chua KYL, Holmes NE, Douglas A, Slavin MA, Cleland H, Zubrinich C, Aung AK, Goh MSY, Phillips EJ, Trubiano JA. (2021) The role of in vivo and ex vivo diagnostic tools in severe delayed immune-mediated adverse antibiotic drug reactions. J Allergy Clin Immunol Pract. 9(5):2010-5. PMCID: 33453452.

  • Copaescu A, Choshi P, Pedretti S, Mouhtouris E, Peter J, Trubiano JA. (2021) Dose-Dependent Antimicrobial Cellular Cytotoxicity - Implications for ex vivo Diagnostics. Frontiers in Pharmacology. 2069. PMCID: 8383281.

  • Copaescu AM, James F, Vogrin S, Rose M, Chua K, Holmes NE, Turner NA, Stone C, Phillips E, Trubiano J. Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomized control trial in an adult population (PALACE): study protocol. BMJ Open. 2022;12(8):e063784. PMID: 35940831.

  • Copaescu AM, Vogrin S, Shand G, Ben-Shoshan M, Trubiano JA. Validation of the PEN-FAST Score in a Pediatric Population. JAMA Netw Open.2022; 1;5(9):e2233703. PMID: 36121658.