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null Ana Copaescu, MD, PhD

Investigator, RI-MUHC, Montreal General Hospital site

Infectious Diseases and Immunity in Global Health Program

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Adult Allergy and Clinical Immunology, MUHC

 

Keywords

immune-mediated adverse drug reactions • ievere cutaneous adverse reaction • point of care solutions • risk stratification tools • in vivo diagnostic tools • ex vivo diagnostic tools • clinical trials

Research Focus

My research focuses on drug allergy−related pathologies, including their clinical identification, diagnostic methods and management. The ongoing clinical and translational research projects aim to improve precision diagnosis, including mechanisms to remove drug allergy labels and develop diagnostic tools. My current clinical and research interests include penicillin and antimicrobial delabelling, aiming to promote the appropriate use of antimicrobial agents through clinical stewardship interventions. Furthermore, I strive to advance our understanding of the complex, severe, delayed drug reactions associated with significant acute and long-term morbidity and mortality. These developments allow me to be part of a network of international collaborators, an excellent platform for exchanging and developing new projects. Addressing the significant health issue of immune-mediated drug allergy will lead to high-level research output that will translate into improvement in healthcare, locally and internationally.

Selected Publications

Click on Pubmed to see my current publications list

  • Copaescu AM, Vogrin S, James F, Chua KYL, Rose MT, De Luca J, Waldron J, Awad A, Godsell J, Mitri E, Lambros B, Douglas A, Youcef Khoudja R, Isabwe GAC, Genest G, Fein M, Radojicic C, Collier A, Lugar P, Stone C, Ben-Shoshan M, Turner NA, Holmes NE, Phillips EJ, Trubiano JA. Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial. JAMA Intern Med. 2023 Sep 1;183(9):944-952. doi: 10.1001/jamainternmed.2023.2986. PMID: 37459086.

  • Copaescu AM, Vogrin S, Douglas A, Turner NA, Phillips EJ, Holmes NE, Trubiano JA. Risk of Self-Reported Penicillin Allergy Despite Removal of Penicillin Allergy Label: Secondary Analysis of the PALACE Randomized Clinical Trial. JAMA Netw Open. 2024 Aug 1;7(8):e2429621. doi: 10.1001/jamanetworkopen.2024.29621. PMID: 39145980.

  • Copaescu AM, Vogrin S, Mouhtouris E, Chua KYL, Holmes NE, Trubiano JA. A multicenter comparative cohort study of severe maculopapular exanthema and drug reaction with eosinophilia and systematic symptoms. J Allergy Clin Immunol Pract. 2024 Dec;12(12):3442-3445.e2. doi: 10.1016/j.jaip.2024.08.057. Epub 2024 Sep 19. PMID: 39306328.

  • Alotaibi I, Khoudja RY, Isabwe GAC, Fein M, Stehlin F, James F, Ben-Shoshan M, Trubiano JA, Copaescu AM. Tolerance of penicillin V in patients with confirmed delayed hypersensitivity reactions to aminopenicillins. J Allergy Clin Immunol Pract. 2024 Oct 23:S2213-2198(24)01073-0. doi: 10.1016/j.jaip.2024.10.018. Epub ahead of print. PMID: 39454676.

  • Copaescu AM, Vogrin S, Shand G, Ben-Shoshan M, Trubiano JA. Validation of the PEN-FAST Score in a Pediatric Population. JAMA Netw Open. 2022 Sep 1;5(9):e2233703. doi: 10.1001/jamanetworkopen.2022.33703. PMID: 36121658.