Breadcrumb

null Andréanne Lupien, PhD

Junior Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Assistant Professor, Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

tuberculosis • non-tuberculous mycobacteria • drug development • tuberculosis preventive treatment • drug resistance • molecular biology

Research Focus

My research mainly focuses on evaluating and developing new treatments against tuberculosis (TB) and non-tuberculous mycobacterial infections. Specifically, I investigate how mycobacteria resist current treatments and aim to develop new therapies. My work includes optimizing new tuberculosis preventive treatments (TPT) for latent TB infections and characterizing new compounds and regimens against Mycobacterium tuberculosis and non-tuberculous mycobacteria from the initial discovery (hit identification and hit-to-lead optimization) to pre-clinical studies.

Selected Publications

Click on Pubmed to see my current publications list

  • Caroline Shi-Yan Foo, Kevin Pethe and Andréanne Lupien. Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis. Review. Appl. Sci. 2020, 10(7), 2339; https://doi.org/10.3390/app10072339.

  • Lupien A*, Foo CS*, Savina S, Vocat A, Piton J, Monakhova N, Benjak A, Lamprecht DA, Steyn AJC, Pethe K, Makarov VA, Cole ST. New 2-Ethylthio-4-methylaminoquinazoline Derivatives Inhibiting Two Subunits of Cytochrome bc1 in Mycobacterium Tuberculosis. PLoS Pathog. 2020 Jan 23;16(1):e1008270. doi: 10.1371/journal.ppat.1008270. eCollection 2020 Jan. PMID: 31971990.

  • Caroline Shi-Yan Foo*, Andréanne Lupien*, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie JC Steyn, Kevin Pethe, Jérémie Piton, Karl Altmann, Stewart T Cole. Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of Mycobacterium tuberculosis. MBio. 2018 Oct 9;9(5). pii: e01276-18. doi: 10.1128/mBio.01276-18. PMID: 30301850.

  • Jaryd R. Sullivan, Jacqueline Yao, Christophe Courtine, Andréanne Lupien, Jennifer Herrmann, Rolf Müller, Marcel A. Behr. Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex. Microbiol Spectr. 2022 Dec 21;10(6):e0267222. doi: 10.1128/spectrum.02672-22. Epub 2022 Oct 31. PMID: 36342177.

  • Shannon C Duffy, Andréanne Lupien, Youssef Elhaji, Mina Farag, Victoria Marcus, Marcel A Behr. Establishment of persistent enteric mycobacterial infection following streptomycin pre-treatment. Gut Pathog. 2023 Oct 3;15(1):46. doi: 10.1186/s13099-023-00573-w. PMID: 37789445.