null Brett Burstein, MDCM, PhD, MPH, FRCPC, FAAP

Junior Scientist, RI-MUHC , Glen site

Child Health and Human Development Program

Centre for Outcomes Research and Evaluation

Assistant Professor, Department of Pediatrics and Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine and Health Sciences, McGill University

Department of Pediatrics, Division of Emergency Medicine, MUHC



Febrile young infants • serious bacterial infections • fever • sepsis • viral testing

Research Focus

Fever among infants in the first three months of life remains one of the most commonly encountered clinical problems in all of pediatric healthcare. Although the majority of these infants have self-limited viral illnesses, approximately 10% harbour potentially life-threatening serious bacterial infections. High-risk infants cannot be identified on the basis of history and physical exam alone. Decisions must be made regarding the extent of investigations as well as the need for antibiotic treatment and hospitalization. My research program aims to improve and standardize the care of febrile young infants, aligned with parental preferences and in view of family-centred outcomes. The overarching goals of this program are first to determine how to safely reduce invasive testing and hospitalization for febrile young infants using currently available and newer diagnostic tools, and second, to better understand parental preferences and identify barriers and facilitators for shared decision-making.

Selected Publications

  • Prevalence of Bacterial Meningitis Among Febrile Infants Aged 29-60 Days With Positive Urinalysis Results: A Systematic Review and Meta-analysis. Burstein B, Sabhaney V, Bone JN, Doan Q, Mansouri FF, Meckler GD. JAMA Netw Open 2021;4(5):e214544. doi:10.1001/jamanetworkopen.2021.4544.

  • Use of Radiography in Patients Diagnosed as Having Acute Bronchiolitis in US Emergency Departments, 2007-2015. Burstein B, Plint AC, Papenburg J. JAMA. 2018 Oct 16;320(15):1598-1600. doi: 10.1001/jama.2018.9245.

  • Suicidal Attempts and Ideation Among Children and Adolescents in US Emergency Departments, 2007-2015. Burstein B, Agostino H, Greenfield B. JAMA Pediatr. 2019 Jun 1;173(6):598-600. doi: 10.1001/jamapediatrics.2019.0464.

  • Emergency Department and Inpatient Clinical Decision Tools for the Management of Febrile Young Infants Among Tertiary Paediatric Centres Across Canada. Burstein B, Gravel J, Aronson PL, Neuman MI; Pediatric Emergency Research Canada (PERC). Paediatr Child Health. 2019 Jun;24(3):e142-e154. doi: 10.1093/pch/pxy126. Epub 2018 Oct 5.

  • National Survey on the Impact of Viral Testing for the ED and Inpatient Management of Febrile Young Infants. Burstein B, Dubrovsky AS, Greene AW, Quach C. Hosp Pediatr. 2016 Apr;6(4):226-33. doi: 10.1542/hpeds.2015-0195. Epub 2016 Jan 1.