null Brian Ward, MD, DTM&H, MDCM
Vaccines • respiratory viruses • international health • parasitology • diagnostics
My research focuses on: the development and evaluation of novel virus-like particle vaccines (eg: influenza, measles) in both young and elderly subjects, international health issues with a particular focus on factors that influence HIV transmission, virus-nutritional interactions, and the development of new diagnostic tests for parasitic diseases. My laboratory sits at the junction between infectious diseases clinic and the basic science laboratory. Projects can start at either end of this spectrum and move from 'bed to the bench-top' or from 'bench-top to the bed'. Most of the basic work is carried out in Montreal with satellite facilities in Peru and Zimbabwe. Human vaccine studies are conducted at the MUHC Vaccine Study Centre in Pierrefonds, QC.
Makarkov AI, Golizeh M, Gopal AA, Costas-Cancelas IN, Chierzi S, Pillet S, Charland N, Landry N, Rouiller I, Wiseman PW, Ndao M, Ward BJ. Plant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages. NPJ Vaccines. 2019 May 15;4:17.
Colmegna I, Useche ML, Rodriguez K, McCormack D, Alfonso G, Patel A, Agnihotram RV, Rahme E, Bernatsky S, Hudson M, Ward BJ. Immunogenicity and safety of high-dose versus standard-dose inactivated influenza vaccine in rheumatoid arthritis patients: a randomised, double-blind, active-comparator trial. Lancet Rheumatology 2020 (in press).
Winter K, Xing L, Kassardjian A, Ward BJ. Vaccination against the receptor binding domain of Clostridium difficile Toxin A and B using a YS1646 Salmonella typhimurium vector protects C57BL/6J mice from lethal challenge. Infection & Immunity 2019 Jul 23;87(8).
Restori K, Srinivasa B, Ward BJ, Fixman ED. Repiratory virus infections in neonates and the immunology of asthma. Front Immunol 2018 Jun 4;9:1249.
Ward BJ, Pillet S, Charland N, Trepanier S, Couillard J, Landry N. The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines? Hum Vaccin Immunother. 2018 Jan 16:1-10.