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angle-left Bruce Mazer, MD

Senior Scientist, RI-MUHC , Glen site

Translational Research in Respiratory Diseases Program

Centre for Translational Biology

Professor, Department of Pediatrics, Faculty of Medicine, McGill University

Department of Pediatrics, Division of Allergy/Immunology/Dermatology, MUHC

 

Keywords


Asthma • food allergy • immune therapies • intravenous immunoglobulin • B-lymphocytes and mucosal responses • antigen presentation • IgE • IVIg • semaphorins

Research Focus


My research focuses on a combination of human studies and animal modeling to determine new ways of changing the immune response to allergens, and to help to naturally shape immune tolerance in individuals with allergies and asthma. Asthma and food allergies affect almost 20% of children in North America. These diseases are important causes of morbidity and mortality, and have a huge economic and social impact.

Selected Publications


Click on Pubmed to see my current publications list

  • Xue D, Kaufman GN, Dembele M, Beland M, Massoud AH, Mindt BC, Fiter R, Fixman ED, Martin JG, Friedel RH, Divangahi M, Fritz JH, Mazer BD. J Immunol. 2017 Jan 1;198(1):71-81. Epub 2016 Nov 23. Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells. PMID: 27881703.

  • Asai Y, Eslami A, van Ginkel CD, Akhabir L, Wan M, Yin D, Ellis G, Ben-Shoshan M, Marenholz I, Martino D, Ferreira MA, Allen K, Mazer B, de Groot H, de Jong NW, Gerth van Wijk R, Dubois AEJ, Grosche S, Ashley S, Rüschendorf F, Kalb B, Beyer K, Nöthen MM, Lee YA, Chin R, Cheuk S, Hoffman J, Jorgensen E, Witte JS, Melles RB, Hong X, Wang X, Hui J, Musk AWB, Hunter M, James AL, Koppelman GH, Sandford AJ, Clarke AE, Daley D. Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma. J Allergy Clin Immunol. 2018 Jan 8. pii: S0091-6749(18)30025-3. PMID: 29325868.

  • Kaufmann E, Sanz J, Dunn JL, Khan N, Mendonça LE, Pacis A, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Mailhot-Léonard F, *Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi M. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018 Jan 11;172(1-2):176-190.e19. PMID: 29328912.

  • Desjardins M, Arjunaraja S, Stinson JR, Dorjbal B, Sundaresan J, Niemela J, Raffeld M, Matthews HF, Wang A, Angelus P, Su HC, Mazer BD, Snow AL. A Unique Heterozygous CARD11 Mutation Combines Pathogenic Features of Both Gain- and Loss-of-Function Patients in a Four-Generation Family. Frontiers in Immunology, 2018 Dec 12;9:2944. PMID: 30619304.

  • De Schryver S, Mazer B, Clarke AE, St Pierre Y, Lejtenyi D, Langlois A, Torabi B, Zhao WW, Chan ES, Baerg I, Ben-Shoshan M. Adverse Events in Oral Immunotherapy for the Desensitization of Cow's Milk Allergy in Children: A Randomized Controlled Trial. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1912-1919. PMID: 30776522.