Asset Publisher

angle-left David Goltzman, MD

Senior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine, McGill University

Department of Medicine, Division of Endocrinology and Metabolism, MUHC

 

Keywords


calcium and mineral metabolism • hormonal regulation • bone metabolism • osteoporosis • parathyroid disorders • cancer and bone • chronic kidney disease-bone and mineral disorder(CKD-MBD)

Research Focus


My research focuses on the laboratory investigation of the hormonal regulation of mineral and skeletal metabolism and also on epidemiologic studies of osteoporosis, the most prevalent form of bone disease.My colleagues and I have examined the demographics, development, risk factors and outcomes of osteoporosis and of osteoporotic fractures. My approach therefore has been to evaluate bone disease in the population, but to anchor these observations with important insights from the laboratory.

Selected Publications


Click on Pubmed to see my current publications list

  • Tanaka KI, Xue Y, Nguyen-Yamamoto L, Morris JA, Kanazawa I, Sugimoto T, Wing SS, Richards JB, Goltzman D. FAM210A is a novel determinant of bone and muscle structure and strength. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3759-E3768. PMID: 29618611.

  • Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet. 2019 Feb;51(2):258-266. PMID: 30598549.

  • Nguyen-Yamamoto L, Karaplis AC, St-Arnaud R, Goltzman D.Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D. J Am Soc Nephrol. 2017 Feb 28(2): 586-597. PMID: 27535551.

  • Bai X, Miao D, Xiao S, Qiu D, St-Arnaud R, Petkovich M, Gupta A, Goltzman D, Karaplis AC. CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders. J Clin Invest. 2016 Feb 1;126(2):667-80. PMID: 26784541.

  • Langsetmo L, Berger C, Kreiger N, Kovacs C S, Hanley D A,. Jamal S A, Whiting S J, Genest J,Morin S N, Hodsman A, Prior J C, Lentle B, Patel M S, Brown JP, Anastasiades T, Towheed T, Josse R G, Papaioannou A, Adachi J D,. Leslie W D, Davison K. S, Goltzman D, and the CaMos Group. Calcium and Vitamin D Intake and Mortality: Results from the Canadian Multi-centre Osteoporosis Study J Clin Endocrinol Metab, 2013 Jul; 98(7):3010-8. PMID: 23703722.