Multiple sclerosis • T-cell biology • MS progression
My research focuses on multiple sclerosis and changes in T-cells that predict rates of disease progression. I am interested in developing biomarkers that distinguish between MS patients having rapid vs. slow disease progression, in particular progression to secondary progressive MS which is the main determinant of long-term prognosis in MS patients.
E. Zastepa, L. Fitz-Gerald, M. Hallett, J. P. Antel. A. Bar-Or, S. Baranzini, Y. Lapierre, D. Haegert, Neurology, Feb 2014.Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS.
Haegert DG. Multiple sclerosis: a disorder of T-cell homeostasis. Mult Scl Int Epub. 2011.