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sedation • neurodevelopment • pharmacokinetics
My research focuses on anesthesia and critical care areas. I am currently involved in an international study of neurodevelopment following anesthesia in infants where we are following children until 5 years of age. I am developing a similar investigation for infants who have received continuous sedation in intensive care during critical illness and am also examining sedation requirements in Inuit infants receiving intensive care. In the pediatric intensive care unit we are about to start a study to see if interupting sedation daily will decrease the overall amount of sedation these children require and make it easier for them to get off a breathing machine. I also have an interest in levels of medications during sedation and in infants supported on a heart-lung machine in intensive care.
D.E. Withington, P.S. Fontela, K.P. Harrington, C. Tchervenkov, L.C. Lands. A comparison of three dose timings of methylprednisolone in infant cardiopulmonary bypass. SpringerPlus.2014, PMID: 25221738.
Andrew J. Davidson, Neil S. Morton, Sarah J. Arnup, Jurgen C. de Graaff, Nicola Disma, Davinia E. Withington, et al for the GAS Consortium). Apnea after awake-regional and general anesthesia in infants: The General Anesthesia compared to Spinal anesthesia (GAS) study: comparing apnea and neurodevelopmental outcomes, a randomized controlled trial. Anesthesiology 2015 PMID: 26001033.
T. R. Holt, E. Mitchell. D. Withington Which pressure to believe? A comparison of direct arterial with indirect blood pressure measurement techniques in the pediatric intensive care unit Pediatric Critical Care Medicine 9 June 2011 PMID: 21666539.
D. Withington, G Ménard, F. Varin. Cisatracurium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children. (2011) Pediatric Anesthesia PMID: 21223452.
P Jouvet, J Hutchison, R Pinto, K Menon, R Rodin, K Choong, M Kesselman, S. Veroukis, M André Dugas, M Santschi, AM Guerguerian, D Withington, B Alsaati, AR Joffe, T Drews, P Skippen, E Rolland, A Kumar, R Fowler, for the Canadian Critical Care Trials Group H1N1 Collaborative. Critical illness in children with influenza A/pH1N1 2009 infection in Canada. Pediatr Crit Care Med 2010 PMID: 20308929.