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null Edward Fon, MD, FRCP(C)

RI-MUHC , Montreal Neurological Institute and Hospital

Brain Repair and Integrative Neuroscience (BRaIN) Program

Montreal Neurological Institute

 

Keywords

Parkinson's disease • Ubiquitin • mitochondria • Parkin • PINK1 • synuclein • LRRK2

Research Focus

My research focuses on movement disorders and on the molecular events leading to the neuronal degeneration in Parkinson's disease (PD). I am particularly interested in the function and cell biology of PD genes. My work in this area aims to provide important clues about disease mechanisms and potentially lead to innovative new therapeutic strategies. My research is supported by the Canadian Institutes of Health Research (CIHR), Parkinson Society Canada and the Michael J. Fox Foundation.

Selected Publications

Click on Pubmed to see my current publications list

  • Trempe J-F*#, Sauvé#, V, Grenier K*, Seirafi, M, Tang MY*, Ménade M, Krett J*, Wong K, Kozlov G, Nagar B, Fon EA§, Gehring K§. Structure of parkin reveals mechanism of ubiquitin ligase activation. Science. 2013 340(6139):1451-5. #Co-first authors; §co-corresponding authors.

  • Fallon L*, Bélanger CML*, Corera AT*, Kontogiannea M*, Regan-Klapisz E, Moreau F*, Voortman J, Haber M*, Rouleau G*, Thorarinsdottir T*, Brice A, van Bergen en Henegouwen P, Fon EA. A Regulated Interaction with the UIM-protein Eps15 Implicates Parkin in EGF Receptor Trafficking and PI3K-Akt Signaling. Nat. Cell Biol. 2006; 8(8):834-42

  • Trempe JF, Chen CXQ*, Grenier K*, Camacho EM, Kozlov G, McPherson PS, Gehring K§, Fon EA§. SH3 Domains from a Subset of BAR-Proteins Define a Novel Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination. Mol. Cell 2009; 36(6):1034-7; §co-corresponding authors

  • Greene AW*, Grenier K*, Aguileta MA*, Muise S* Farazi R, Haque ME, McBride HM, Park DS, Fon EA. Mitochondrial Processing Peptidase Regulates PINK1 Processing, Import and Parkin Recruitment. EMBO Rep. 2012; 13(4):378-85

  • Durcan TM*, Kontogiannea M*, Thorarinsdottir T*, Fallon L*, Williams AJ, Djarmati A, Fantaneanu T*, Paulson HL, Fon EA. The Machado-Joseph Disease-Associated Mutant form of Ataxin-3 Regulates Parkin Ubiquitination and Stability. Hum. Mol. Genet. 2011; 20(1):141-4