Research Institute of the McGill University Health Centre
Regular Member Neurosciences
McGill University Health Centre (MUHC)
Montreal Neurological Institute, Department of Neurology and Neurosurgery
My research focuses on movement disorders and on the molecular events leading to the neuronal degeneration in Parkinson's disease (PD). I am particularly interested in the function and cell biology of PD genes. My work in this area aims to provide important clues about disease mechanisms and potentially lead to innovative new therapeutic strategies. My research is supported by the Canadian Institutes of Health Research (CIHR), Parkinson Society Canada and the Michael J. Fox Foundation.
- cell biology of Parkinson's disease genes
- role of Parkin and PINK1 in mitochondrial quality-control
- understanding Ubiquitination pathways in Parkinson's disease
- cell-to-cell propagation of a-Synuclein
- role of LRRK2 in cytoskeletal dynamics and trafficking
Parkinson's disease, Ubiquitin, mitochondria, Parkin, PINK1, synuclein, LRRK2
Trempe J-F*#, Sauvé#, V, Grenier K*, Seirafi, M, Tang MY*, Ménade M, Krett J*, Wong K, Kozlov G, Nagar B, Fon EA§, Gehring K§. Structure of parkin reveals mechanism of ubiquitin ligase activation. Science. 2013 340(6139):1451-5. #Co-first authors; §co-corresponding authors.
Fallon L*, Bélanger CML*, Corera AT*, Kontogiannea M*, Regan-Klapisz E, Moreau F*, Voortman J, Haber M*, Rouleau G*, Thorarinsdottir T*, Brice A, van Bergen en Henegouwen P, Fon EA. A Regulated Interaction with the UIM-protein Eps15 Implicates Parkin in EGF Receptor Trafficking and PI3K-Akt Signaling. Nat. Cell Biol. 2006; 8(8):834-42
Trempe JF, Chen CXQ*, Grenier K*, Camacho EM, Kozlov G, McPherson PS, Gehring K§, Fon EA§. SH3 Domains from a Subset of BAR-Proteins Define a Novel Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination. Mol. Cell 2009; 36(6):1034-7; §co-corresponding authors
Greene AW*, Grenier K*, Aguileta MA*, Muise S* Farazi R, Haque ME, McBride HM, Park DS, Fon EA. Mitochondrial Processing Peptidase Regulates PINK1 Processing, Import and Parkin Recruitment. EMBO Rep. 2012; 13(4):378-85
Durcan TM*, Kontogiannea M*, Thorarinsdottir T*, Fallon L*, Williams AJ, Djarmati A, Fantaneanu T*, Paulson HL, Fon EA. The Machado-Joseph Disease-Associated Mutant form of Ataxin-3 Regulates Parkin Ubiquitination and Stability. Hum. Mol. Genet. 2011; 20(1):141-4