pharmacoepidemiology • drug utilisation • drug adverse events • tumour necrosis factor inhibitors • anticoagulants • mental disorders
My research program focuses on the evaluation of the safety, effectiveness and economic implications of prescribed medications using large administrative databases and on the development of new biostatistical methods for the design and analyses of such studies. The Quebec health administrative databases are a resource for several of my projects in the pharmacoepidemiology domain. We are assessing the effectiveness and safety of the biologic medications (anti-TNF) in the treatment of rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease and psoriasis; the risk of mental health disorders and suicide in patients with autoimmune diseases; and the use and safety, in terms of risk of major bleeding, of new oral anticoagulants in the prevention of stroke in atrial fibrillation as well as in the secondary prevention of venous thromboembolism. In terms of methodology development, my current research includes the validation of methods used to correct for outcome misclassification including multiple imputation and Bayesian methods.
Ni J, Dasgupta K, Kahn S, Talbot D, Lefebvre G, Lix LM, Berry G, Burman M, Dimentberg R, Laflamme Y, Cirkovic A, Rahme E. Comparing external and internal validation methods in correcting outcome misclassification bias in logistic regression: a simulation study and application to the case of post-surgical venous thromboembolism following total hip and knee arthroplasty. Pharmacoepidemiology and Drug safety. 2018 December 4. 1-10. Doi: 10.1002/pds.4693.
Mikhail A, Tanoli O, Légaré G, Dubé PA, Habel Y, Lesage A, Low NCP, Lamarre S, Singh S, Rahme E. Over-the-counter drugs and other substances used in attempted suicide presented to emergency departments in Montreal, Canada. Crisis- The Journal of Crisis Intervention and Suicide Prevention. 2018 Sep 14:1-10. doi: 10.1027/0227-5910/a000545.
Abou Khalil M, Boutros M, Nedjar H, Morin N, Ghitulescu G, Vasilevsky CA, Gordon P, Rahme E. Incidence Rates and Predictors of Colectomy for Ulcerative Colitis in the Era of Biologics: Results from a Provincial Database. J Gastrointest Surg. 2018 Jan;22(1):124-132. doi: 10.1007/s11605-017-3530-y.
Acurcio FA, Moura CS, Bernatsky S, Bessette L, Rahme E. Opioid use and risk of non-vertebral fractures in adults with rheumatoid arthritis: A nested case-control study using administrative databases. Arthritis Rheumatol. 2015 Sep 11. doi: 10.1002/art.39422.
Leong A, Dasgupta K, Rahme E. Estimating the population prevalence of diagnosed and undiagnosed diabetes. Diabetes Care 2013 Oct;36(10):3002-8.