Errol Marliss, MD, FRCPC - Research Institute of the McGill University Health Centre
Nutrition • metabolism • diabetes • obesity • insulin resistance
My collaborative clinical research focuses on the metabolic alterations in type 2 diabetes and obesity, particularly those implicating protein metabolism. My colleagues have demonstrated that whenever insulin resistance of glucose metabolism occurs, that of protein anabolism does as well. We have also shown, by increasing protein (amino acid) supply, that the resisitance can be overcome. In a recent fMRI study we showed that brain activity in cognitive control regions, rather than hormones controlling energy balance, plays a critical role in weight loss. We are presently providing deep metabolic phenotyping in a multi-omic study of the heterogeneity of type 2 diabetes.
Neseliler, S, Hu, W., Zacchia M., Larcher, K., Dadar, M., Scala, S.G., Lamarche, M., Zeighami, Y., Stotland, S.C., Laroque, M., Marliss, E.B., Dagher, A. Neurocognitive and Hormonal Correlates of Voluntary Weight Loss in Humans, Cell metabolism, Cell metabolism, 29:1–11, 2019. PMID: 30344017.
Neseliler, S, Tannenbaum, B., Zacchia, M., Larcher, K., Coulter, K., Lamarche, M., Marliss, E.B., Pruessner, J., Dagher, A. Stress and personality interact to modulate the neural response to food cues. Appetite. 116: 306–314, 2017. doi: 10.1016/j.appet.2017.05.016 PMID: 28487246.
Burgos, S.A., Chandurkar, V., Tsoukas, M.A., Chevalier, S., Morais, J.A., Lamarche M., Marliss, E.B. Insulin Resistance of Protein Anabolism accompanies that of Glucose Metabolism in Lean, Glucose-tolerant Offspring of Persons with Type 2 Diabetes. BMJ Open Diabetes Research and Care 2016; 4:e000312. PMID: 27933189.
Labonte, C., Farsijani, S., Marliss, E.B., Gougeon, R., Morais, J.A., Combs, T.P., Pereira, S., Bassil, M., Winter, A, Murphy, J., Combs, T.P., Chevalier, S. Plasma amino acids versus conventional predictors of insulin resistance measured by the hyperinsulinemic, euglycemic clamp. Journal of the Endocrine Society, online Apr 27 2017. doi: 10.1210/js.2016-1108. PMID: 29264537.
Chevalier, S., Burgos, S.A., Morais, J.A., Gougeon, R., Bassil, M., Lamarche, M, Marliss EB. Protein and glucose metabolism response to hyperinsulinemia, hyperglycemia and hyperaminoacidemia in obese, glucose tolerant men. Obesity 23: 351-358, 2015. Published online Dec 1, 2014. doi: 10.1002/oby.20943.