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systemic lupus erythematosus • rheumatoid arthritis • female reproductive health • epidemiology • pregnancy and rheumatic diseases • administrative databases • perinatal outcomes
The primary goal of my research program is to use epidemiologic methods to improve reproductive health outcomes in women with rheumatic diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), and their offspring. To this end, I have created the world's largest cohort of offspring from SLE women, which has driven our novel findings demonstrating that SLE offspring are at increased risk of autism spectrum disorders, congenital heart defects, and stillbirths. I am also actively spear-heading research initiatives to elucidate how therapies used to treat rheumatic diseases (e.g. TNF-inhibitors and other biologics) impact health outcomes in these patients and their offspring.
Research areas: Clinical Epidemiology; Rheumatic Diseases; Non-Communicable Disease Epidemiology; Pharmacoepidemiology; Population and Public Health
Vinet É, Pineau CA, Scott S, Clarke AE, Platt RW, Bernatsky S. Increased congenital heart defects in children born to women with systemic lupus erythematosus: results from the offspring of Systemic Lupus Erythematosus Mothers Registry Study. Circulation. 2015 Jan 13;131(2):149-56. doi: 10.1161/CIRCULATIONAHA.114.010027. Epub 2014 Oct 29. PMID: 25355915.
Vinet É, Kuriya B, Pineau CA, Clarke AE, Bernatsky S. Induced abortions in women with rheumatoid arthritis receiving methotrexate. Arthritis Care Res (Hoboken). 2013 Aug;65(8):1365-9. doi: 10.1002/acr.22000. PMID: 23908006.
Vinet E, Clarke AE, Gordon C, Urowitz MB, Hanly JG, Pineau CA, Isenberg D, Rahman A, Wallace D, Alarcón GS, Bruce I, Petri M, Dooley MA, Kalunian K, Maddison P, Aranow C, van Vollenhoven R, Bernatsky S. Decreased live births in women with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2011 Jul;63(7):1068-72. doi: 10.1002/acr.20466. PMID: 21425248.
Vinet É, Bernatsky S, Hudson M, Pineau CA, Baron M; Canadian Scleroderma Research Group. Effect of menopause on the modified Rodnan skin score in systemic sclerosis. Arthritis Res Ther. 2014 Jun 23;16(3):R130. doi: 10.1186/ar4587. PMID: 24957704.
Vinet E, Labrecque J, Pineau CA, Clarke AE, St-Pierre Y, Platt R, Bernatsky S. A population-based assessment of live births in women with systemic lupus erythematosus. Ann Rheum Dis. 2012 Apr;71(4):557-9. doi: 10.1136/annrheumdis-2011-200276. Epub 2011 Nov 14. PMID: 22084391.