stem cell transplantation • malignant hematology • leukemia • post-transplant infections
My research focuses on many aspects of adult allogeneic hematopoietic stem cell transplantation (HSCT) including outcomes and processes specific to transplantation. HSCT is a procedure that can cure hematological malignancies and bone marrow failure syndromes, as well as restore normal hematopoietic function and replace a sick immune system with a healthy one. Although its successes are well documented, HSCT is associated with many complications that may limit is utility, and is dependent on transplant donor availability and characteristics. A better understanding of both may improve HSCT patient outcomes and make it a safer and more broadly applicable therapy.
Walker I, Panzarella T, Couban S, Couture F, Devins G, Elemary m, Gallagher G, Kerr H, Kuruvilla J, Lee S, Nevill T, Popradi G, Roy J, Schultz K, Szwajcer D, Toze C, Foley R. A randomized trial of ATG in unrelated donor hematopoietic cell transplantation. . NEJM, July 2015.
Peletier,L, Brown R, Monczak Y, Popradi G, Storring, JM, Laneuville, P. Development of a New Third-Party Unit for Adult Stem CellTransplantation using Clinical-Grade Rejected Cord Blood Units. J Genet Syndr Gene Ther 2014, 6: 254.
Mack, JP, Tan, X, Vinh DC, Popradi G. Risk Factors for Progression of CMV Viremia to CMV Disease after Allogeneic Hematopoietic Stem Cell Transplantation. Abstract, 2015 BMT Tandem Meetings, San Diego. Biology of Blood and Marrow Transplant, Vol. 21, Issue 2, S296-S297. Published in issue: February 2015.
Kim DH, Popradi G, Xu W, Gupta V, Kuruvilla J, Wright J, Messner HA, Lipton JH. Peripheral blood eosinophilia has a favorable prognostic impact on transplant outcomes after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 2009 Apr;15(4):471-82. PMID: 19285635.
Long-term remission after autologous stem-cell transplantation for relapsed histiocytic sarcoma. Abu-Sanad A, Warsi A, Michel RP, Nahal A, Popradi G, Storring JM, Liberman AS, Alcindor T.Curr Oncol. 2012. Aug;19(4):e289-91. PMID: 22876158.