null Guilherme Sant'Anna, MD, PhD

Scientist, RI-MUHC

Translational Research in Respiratory Diseases Program

Centre for Outcomes Research and Evaluation

Associate Professor, Department of Pediatrics, Faculty of Medicine, McGill University

Department of Pediatrics, Division of Neonatology, MUHC



neonatal invasive and non-invasive ventilation • hypoxic-ischemic encephalopathy • heart rate variability

Research Focus

My research focuses on understanding and optimizing the respiratory assistance that some preterm infants require after birth, as well as the pathophysiology, management and outcomes of asphyxiated neonates. My respiratory research program is the EXPERT Project, Extremely Preterm Infants on Respiratory Therapy. This project investigates ways to optimize invasive and non-invasive respiratory therapy and therefore promote a continuous and timely transition toward no respiratory support. In collaboration with Biomedical Engineering and Computer Science at McGill University, we are working on the development of an automated system for prediction of extubation readiness in extremely preterm infants (the APEX study). We are also studying the mechanisms of action of non-invasive support therapies, and the impact of the development and implementation of respiratory care protocols. Other projects include two international collaborations: the prospective research of infants with mild hypoxic-ischemic encephalopathy (PRIME study) and the neurophysiological maturation of moderate and late preterm infants (NEMO project).

Selected Publications

Click on Pubmed to see my current publications list

  • Prempunpong C, Efanov I, Sant'Anna G. Serum calcium concentrations and incidence of hypocalcemia in infants with moderate or severe hypoxic-ischemic encephalopathy: Effect of therapeutic hypothermia. Early Hum Dev. 2015 Sep;91(9):535-40. doi: 10.1016/j.earlhumdev.2015.06.008. Epub 2015 Jul 12. PMID: 26172341.

  • Nouraeyan N, Lambrinakos-Raymond A, Leone M, Sant'Anna G. Surfactant administration in neonates: A review of delivery methods. Can J Respir Ther. 2014 Fall;50(3):91-5. PMID: 26078618.

  • Al-Mandari H, Shalish W, Dempsey E, Keszler M, Davis PG, Sant'Anna G. International survey on periextubation practices in extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2015 Sep;100(5):F428-31. doi: 10.1136/archdischild-2015-308549. Epub 2015 Jun 10. PMID: 26063193.

  • Robles-Rubio CA, Kaczmarek J, Chawla S, Kovacs L, Brown KA, Kearney RE, Sant Anna GM. Automated analysis of respiratory behavior in extremely preterm infants and extubation readiness. Pediatr Pulmonol. 2015 May;50(5):479-86. doi: 10.1002/ppul.23151. Epub 2015 Jan 20. PMID: 25603969.