null Guilherme Sant'Anna, MD, PhD
neonatal invasive and non-invasive ventilation • hypoxic-ischemic encephalopathy • heart rate variability
My research focuses on understanding and optimizing the respiratory assistance that some preterm infants require after birth, as well as the pathophysiology, management and outcomes of asphyxiated neonates. My respiratory research program is the EXPERT Project, Extremely Preterm Infants on Respiratory Therapy. This project investigates ways to optimize invasive and non-invasive respiratory therapy and therefore promote a continuous and timely transition toward no respiratory support. In collaboration with Biomedical Engineering and Computer Science at McGill University, we are working on the development of an automated system for prediction of extubation readiness in extremely preterm infants (the APEX study). We are also studying the mechanisms of action of non-invasive support therapies, and the impact of the development and implementation of respiratory care protocols. Other projects include two international collaborations: the prospective research of infants with mild hypoxic-ischemic encephalopathy (PRIME study) and the neurophysiological maturation of moderate and late preterm infants (NEMO project).
Shalish W, Latremouille S, Papenburg J, Sant'Anna GM. Predictors of extubation readiness in preterm infants: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1): F89-F97.
Shalish W, Kanbar L, Kovacs L, Chawla S, Keszler M, Rao S, Panaitescu B, Laliberte A, Precup D, Brown K, Kearney RE, Sant'Anna GM. The Impact of Time Interval between Extubation and Reintubation on Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants. J Pediatr. 2019 Feb; 205:70-76.
Chalak LF, Adams-Huet B, Sant'Anna G. A Total Sarnat Score in Mild Hypoxic-ischemic Encephalopathy Can Detect Infants at Higher Risk of Disability. J Pediatr. 2019 Nov;214:217-221.
Shalish W, Kanbar L, Kovacs L, Chawla S, Keszler M, Rao S, Latremouille S, Precup D, Brown K, Kearney RE, Sant'Anna GM. Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates. JAMA Pediatr. 2020 Feb 1;174(2):178-185.
Shalish W, Keszler M, Davis P and Sant'Anna GM. The Decision to Extubate in Extremely Preterm Infants: Art, Science, or Gamble? Arch Dis Child Fetal Neonatal Ed.10.1016/j.semperi.2020.151357.