Guillaume Sébire, MD, PhD - Research Institute of the McGill University Health Centre
perinal brain injury • neuroinflammation • hypoxia-ischemia
My research focuses on stroke and infectious/inflammatory aggressions occurring in the developing brain and responsible for severe handicaps, ie cerebral palsy, learning disabilities and behaviourial disorders such as autism. Through a combination of clinical and experimental approaches, our team has shown that prenatal exposure to bacterial components induces cerebral lesions, through cytokines'release, and predisposes to circulatory defects which occur immediately after birth.
Braun KP, Bulder MM, Chabrier S, Kirkham FJ, Uiterwaal CS, Tardieu M, Sébire G. The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke. Brain. 2009 Feb;132(Pt 2):544-57. doi: 10.1093/brain/awn313. PMID 19039009.
Girard S, Tremblay L, Lepage M, Sébire G. IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation. J Immunol. 2010 Apr 1;184(7):3997-4005. doi: 10.4049/jimmunol.0903349. PMID: 20181892.
Girard S, Sébire H, Brochu ME, Briota S, Sarret P, Sébire G. Post-natal administration of IL-1ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries. Brain Behav Immun. 2012 Nov;26(8):1331-9. doi: 10.1016/j.bbi.2012.09.001. PMID: 22982341.
Bergeron JD, Deslauriers J, Grignon S, Fortier LC, Lepage M, Stroh T, Poyart C, Sébire G. White matter injury and autistic-like behavior predominantly affecting male rat offspring exposed to group B streptococcal maternal inflammation. Dev Neurosci. 2013;35(6):504-15. doi: 10.1159/000355656. PMID: 24246964.
Savard A, Brochu ME, Chevin M, Guiraut C, Grbic D, Sébire G. Neuronal self-injury mediated by IL-1beta and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia. J Neuroinflammation. 2015 May 30;12:111. doi: 10.1186/s12974-015-0330-8. PMID: 25343331.