null Gustavo Duque, MD, PhD

Senior Scientist, RI-MUHC

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University



osteoporosis • sarcopenia • osteosarcopenia • aging • geriatrics • gerontology • geroscience • bone • muscle • fat

Research Focus

My research focuses on the interactions between bone, muscle and fat and the elucidation of common mechanisms and pathways associated with the pathophysiology of osteoporosis, sarcopenia, osteosarcopenia and frailty in older persons. I am also looking at the effect of vitamin D, exercise and nutrition on bone and muscle mass while also working on the development of novel diagnostic and therapeutic approaches to age-related musculoskeletal diseases.

Selected Publications

Click on Pubmed to see my current publications list

  • Borda MG, Duque G, Pérez-Zepeda MU, Baldera JP, Westman E, Zettergren A, Samuelsson J, Kern S, Rydén L, Skoog I, Aarsland D. Using magnetic resonance imaging to measure head muscles: An innovative method to opportunistically determine muscle mass and detect sarcopenia. J Cachexia Sarcopenia Muscle. 2023 Dec 4. doi: 10.1002/jcsm.13362. Epub ahead of print. PMID: 38050325.

  • de Souto Barreto P, Rolland Y, Ferrucci L, Arai H, Bischoff-Ferrari H, Duque G, Fielding RA, Beard JR, Muscedere J, Sierra F, Vellas B, LeBrasseur NK. Looking at frailty and intrinsic capacity through a geroscience lens: the ICFSR & Geroscience Task Force. Nat Aging. 2023 Nov 20. doi: 10.1038/s43587-023-00531-w.

  • Smith C, Sim M, Dalla Via J, Levinger I, Duque G. The Interconnection Between Muscle and Bone: A Common Clinical Management Pathway. Calcif Tissue Int. 2023 Nov 3. doi: 10.1007/s00223-023-01146-4.

  • Feehan J, Jacques M, Kondrikov D, Eynon N, Wijeratne T, Apostolopoulos V, Gimble JM, Hill WD, Duque G. Circulating Osteoprogenitor Cells Have a Mixed Immune and Mesenchymal Progenitor Function in Humans. Stem Cells. 2023 Nov 5;41(11):1060-1075. doi: 10.1093/stmcls/sxad064.

  • Zanker J, Scott D, Szoeke C, Vogrin S, Patel S, Blackwell T, Bird S, Kirk B, Center J, Alajlouni DA, Gill T, Jones G, Pasco JA, Waters DL, Cawthon PM, Duque G. Predicting Slow Walking Speed From a Pooled Cohort Analysis: Sarcopenia Definitions, Agreement, and Prevalence in Australia and New Zealand. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2415-2425. doi: 10.1093/gerona/glad165.