null Howard Margolese, MD, M.Sc., FRCPC

Investigator, RI-MUHC

Brain Repair and Integrative Neuroscience (BRaIN) Program

Associate Professor, Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University



psychopharmacology • first episode psychosis • schizophrenia • clinical trials

Research Focus

My research focuses on better understanding the early phases of psychosis and psychotic illnesses. I hope to be able to help patients and their families better understand the factors that can help them heal, so that they can achieve a more positive treatment outcome. I am also interested in helping those with more established Schizophrenia and related psychoses function to the best of their ability. Most of my research focuses on treatment with medications and in exploring how medications impact the trajectory of illness.

Selected Publications

Click on Pubmed to see my current publications list

  • Desmarais JE, Beauclair L, Kolivakis TT, Belanger MC, Annable L, Margolese HC. Effects of discontinuing anticholinergic treatment on movement disorders, cognition and psychopathology in schizophrenia patients. Therapeutic Advances in Psychopharmacology 2014; 4(6):257-267. PMID: 25489477.

  • AlAqeel B, Margolese HC. Remission in Schizophrenia: Critical and systematic review. Harvard Review of Psychiatry 2012 Nov-Dec;20(6):281-97. PMID: 23216066.

  • Desmarais JE, Beauclair L, Margolese HC. Anticholinergics in the era of atypical antipsychotics : short-term or long-term treatment? J Psychopharmacology 2012. 26: 1167-1174. PMID: 22651987.

  • Margolese HC, Chouinard G, Kolivakis TT, Beauclair L, Miller R. Tardive Dyskinesia in the Era of Typical an Atypical Antipsychotics (Part 1): Pathophysiology and Mechanisms of Induction. Can J Psychiatry 2005; 50:541-547. PMID: 16262110.

  • Chouinard G, Margolese HC. Manual for the Extrapyramidal Symptom Rating Scale (ESRS). Schizophrenia Research 2005, 76:247-265. PMID: 15949657.