asthma • immunology • cysteinyl leukotrienes • airway remodeling • epidermal growth factor receptor
My research focuses on the exploration of asthma through the use of animal and cellular models with a particular focus on structural airway changes that result from exposure to allergens. I am investigating the role of the epidermal growth factor receptor in epithelial and smooth muscle proliferation and differentiation as well as the biological significance of heparin-binding epidermal growth factor receptor expression by T cells. I am also exploring the role of cysteinyl leukotrienes and their receptors in the response to oxidative injury resulting from inhalation of chlorine. My clinical interests are related to refractory or difficult-to- treat asthma.
Shalaby KH, Jo T, Nakada E, Allard-Coutu A, Tsuchiya K, Hirota N, Qureshi ST, Maghni K, Rioux CR, Martin JG. ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol. 2012 Sep 15;189(6):2793-804. doi: 10.4049/jimmunol.1201194. Epub 2012 Aug 20. PMID: 22908333.
Hirota N, McCuaig S, O'Sullivan MJ, Martin JG. Serotonin augments smooth muscle differentiation of bone marrow stromal cells. Stem Cell Res. 2014 May;12(3):599-609. doi: 10.1016/j.scr.2014.02.003. Epub 2014 Feb 13. PMID: 24595007.
O'Sullivan MJ, Hirota N, Martin JG. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One. 2014 Apr 17;9(4):e95566. doi: 10.1371/journal.pone.0095566. eCollection 2014. PMID: 24743449.
McGovern TK, Goldberger M, Allard B, Farahnak S, Hamamoto Y, O'Sullivan M, Hirota N, Martel G, Rousseau S, Martin JG. Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse. Am J Respir Cell Mol Biol. 2015 Apr;52(4):513-22. doi: 10.1165/rcmb.2013-0430OC. PMID: 25192041.
Al Heialy S, Zeroual M, Farahnak S, McGovern T, Risse PA, Novali M, Lauzon AM, Roman HN, Martin JG. Nanotubes connect CD4+ T cells to airway smooth muscle cells: novel mechanism of T cell survival. J Immunol. 2015 Jun 15;194(12):5626-34. doi: 10.4049/jimmunol.1401718. Epub 2015 May 1. PMID: 25934863.