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null James Martin, MD

Senior Scientist, RI-MUHC, Glen site

Translational Research in Respiratory Diseases Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Respiratory Medicine, MUHC

 

Keywords

asthma • immunology • cysteinyl leukotrienes • airway remodeling • epidermal growth factor receptor

Research Focus

My research focuses on the exploration of asthma through the use of animal and cellular models with a particular focus on structural airway changes that result from exposure to allergens. I am investigating the role of the epidermal growth factor receptor in epithelial and smooth muscle proliferation and differentiation as well as the biological significance of heparin-binding epidermal growth factor receptor expression by T cells. I am also exploring the role of cysteinyl leukotrienes and their receptors in the response to oxidative injury resulting from inhalation of chlorine. My clinical interests are related to refractory or difficult-to- treat asthma.

Selected Publications

Click on Pubmed to see my current publications list

  • Shalaby KH, Jo T, Nakada E, Allard-Coutu A, Tsuchiya K, Hirota N, Qureshi ST, Maghni K, Rioux CR, Martin JG. ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma. J Immunol. 2012 Sep 15;189(6):2793-804. doi: 10.4049/jimmunol.1201194. Epub 2012 Aug 20. PMID: 22908333.

  • Hirota N, McCuaig S, O'Sullivan MJ, Martin JG. Serotonin augments smooth muscle differentiation of bone marrow stromal cells. Stem Cell Res. 2014 May;12(3):599-609. doi: 10.1016/j.scr.2014.02.003. Epub 2014 Feb 13. PMID: 24595007.

  • O'Sullivan MJ, Hirota N, Martin JG. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells. PLoS One. 2014 Apr 17;9(4):e95566. doi: 10.1371/journal.pone.0095566. eCollection 2014. PMID: 24743449.

  • McGovern TK, Goldberger M, Allard B, Farahnak S, Hamamoto Y, O'Sullivan M, Hirota N, Martel G, Rousseau S, Martin JG. Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse. Am J Respir Cell Mol Biol. 2015 Apr;52(4):513-22. doi: 10.1165/rcmb.2013-0430OC. PMID: 25192041.

  • Al Heialy S, Zeroual M, Farahnak S, McGovern T, Risse PA, Novali M, Lauzon AM, Roman HN, Martin JG. Nanotubes connect CD4+ T cells to airway smooth muscle cells: novel mechanism of T cell survival. J Immunol. 2015 Jun 15;194(12):5626-34. doi: 10.4049/jimmunol.1401718. Epub 2015 May 1. PMID: 25934863.