null Joanna Przybyl, PhD

Junior Scientist, RI-MUHC, Glen site

Cancer Research Program

Centre for Translational Biology

Assistant Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University



sarcoma • liquid biopsy • metabolic reprogramming • translational research • multiomics

Research Focus

In my research I employ multi-omic high-throughput experimental methods and bioinformatic tools to discover new therapeutic targets and markers for diagnosis and classification of soft tissue sarcomas. The goal of my research is to develop clinically applicable assays and investigate new therapeutic approaches that will improve care for patients with soft tissue tumours.

Selected Publications

Click on Pubmed to see my current publications list

  • Tolwani A, Matusiak M, Bui, N, Forgo E, Varma S, Baratto L, Iagaru A, Lazar AJ, van de Rijn M, Przybyl J. Prognostic relevance of the hexosamine biosynthesis pathway activation in leiomyosarcoma. npj Genomic Medicine. 2021 May 3;6(1):30. doi: 10.1038/s41525-021-00193-w. PMID: 33941787.

  • Przybyl J*, Chabon JJ*, Spans L, Ganjoo K, Vennam S, Newman AM, Forgó E, Varma S, Zhu S, Debiec-Rychter M, Alizadeh AA, Diehn M, van de Rijn M. Combination approach for detecting different types of alterations in circulating tumor DNA in leiomyosarcoma. Clin Cancer Res. 2018 Jun 1;24(11):2688-2699. PMID: 29463554.

  • Przybyl J, Spans L, Lum D, Zhu S, Vennam S, Forgó E, Varma S, Ganjoo K, Hastie T, Bowen R, Debiec-Rychter M, van de Rijn M. Detection of circulating tumor DNA in patients with uterine leiomyomas. JCO Precision Oncology. 2019 Oct 16;3:1-9. PMID: 32232185.

  • Przybyl J, Spans L, Ganjoo K, Bui N, Mohler D, Norton J, Poultsides G, Debiec-Rychter M, van de Rijn M. Detection of MDM2 amplification by shallow whole genome sequencing of cell-free DNA of patients with dedifferentiated liposarcoma. PLoS One. 2022 Jan 5;17(1):e0262272. PMID: 34986184.

  • Lagarde P*, Przybyl J*, Brulard C, Pérot G, Pierron G, Delattre O, Sciot R, Wozniak A, Schöffski P, Terrier P, Neuville A, Coindre JM, Italiano A, Orbach D, Debiec-Rychter M, Chibon F. Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol. 2013 Feb 10;31(5):608-15. PMID: 23319690.