Breadcrumb

null John Bergeron, D. Phil.

Honorary Investigator, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

quantitative proteomics • subcellular Fractionation • electron microscopy • systems biology • protein secretion and endocytosis

Research Focus

John Bergeron received an Honorary Investigator appointment to the Research Institute of the McGill University Health Centre (RI-MUHC) in September 2023. This appointment recognizes his major scientific contributions in the area of cellular trafficking, including seminal discoveries in calnexin biology that have earned an enduring place in the textbooks of cell biology. In addition, our research community is indebted to his foundational efforts in the field of proteomics, not only at the RI-MUHC and McGill University, but through his contribution to the establishment of the global Human Proteome Organization.

John Bergeron pioneered research to characterize the complement of proteins found in organelles, which are small intracellular compartments responsible for cell homeostasis. Now a professor emeritus, he has distinguished himself through his highly cited studies of the proteins in human and animal organs, uncovering their functions in health and disease. Among numerous accolades, he has been awarded the Order of Canada, Chevalier de l'Ordre national du Québec, the Human Proteome Organization Discovery Award, the McGill University Medal for Exceptional Academic Achievement, and the Research Canada Leadership Award for his advocacy of Canadian health research.

Selected Publications

Click on Pubmed to see my current publications list

  • Au CE1, Hermo L2, Byrne E1, Smirle J1, Fazel A1, Simon PH1, Kearney RE3, Cameron PH1, Smith CE2, Vali H2, Fernandez-Rodriguez J4, Ma K5, Nilsson T1, Bergeron JJ6. Expression, Sorting and Segregation of Golgi Proteins during Germ Cell Differentiation in the testis. Mol Biol Cell. 2015 Mar 25. pii: mbc.E14-12-1632. [Epub ahead of print]. PMID: 25808494.

  • Smirle J1, Au CE, Jain M, Dejgaard K, Nilsson T, Bergeron J. Cell biology of the endoplasmic reticulum and the Golgi apparatus through proteomics. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a015073. doi: 10.1101/cshperspect.a015073. PMID: 23284051.

  • Bell AW, Deutsch EW, Au CE, Kearney RE, Beavis R, Sechi S, Nilsson T, Bergeron JJ; HUPO Test Sample Working Group. A HUPO test sample study reveals common problems in mass spectrometry-based proteomics. Nat Methods. 2009 Jun;6(6):423-30. doi: 10.1038/nmeth.1333. PMID: 19448641.

  • Gilchrist A1, Au CE, Hiding J, Bell AW, Fernandez-Rodriguez J, Lesimple S, Nagaya H, Roy L, Gosline SJ, Hallett M, Paiement J, Kearney RE, Nilsson T, Bergeron JJ. Quantitative proteomics analysis of the secretory pathway. Cell. 2006 Dec 15; 127(6): 1265-81. PMID: 17174899.

  • Gagnon E1, Duclos S, Rondeau C, Chevet E, Cameron PH, Steele-Mortimer O, Paiement J, Bergeron JJ, Desjardins M. Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell. 2002 Jul 12;110(1):119-31. PMID: 12151002.