null José Morais, MD
protein requirements • muscle protein kinetics • sarcopenia • insulin resistance • aging
My research focuses on the assessment of whole-body and muscle protein metabolism and protein requirements with age and in states of insulin resistance, including diabetes in older adults, using stable isotope methods. Recently, we have been assessing the cellular regulatory mechanisms overseeing muscle protein synthesis and breakdown and its relationship with sarcopenia. Several of my studies involve the nutritional assessment of healthy and frail elderly persons with the aim of improving their nutritional status and level of physical function.
Murphy J, Chevalier S, Gougeon R, Goulet EDB, Morais JA. Insulin resistance of protein metabolism in obese elderly women with and without type 2 diabetes. Exp Gerontol 2015 Jun 8;69:20-26. doi: 10.1016/j.exger.2015.06.008.
Matta J, Mayo N, Dionne IJ, Gaudreau P, Fulop T, Tessier D, Gray-Donald K, Shatenstein B, Scott S, Morais JA. Muscle mass index and animal source of protein intake are positively associated with insulin resistance in elderly participants of the NuAge Study. J Nutr Health Aging. 2016 Feb;20(2):90-7. doi: 10.1007/s12603-015-0554-4.
Morais JA, Jacob KW, Chevalier S. Effects of Aging and Insulin Resistant States on Protein Anabolic Responses in Older Adults. Exp Gerontol. 2018 Jul 15;108:262-268. doi: 10.1016/j.exger.2018.04.025.
Sonjak V, Jacob KW, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT. Reduced Mitochondrial Content, Elevated ROS and Modulation by Denervation in Skeletal Muscle of Pre-frail/Frail Elderly Women. J Gerontol A Biol Sci Med Sci. 2019 Mar 11. pii: glz066. doi: 10.1093/gerona/glz066.
Jacob KW, Chevalier S, Lamarche M, Morais JA. Leucine supplementation does not alter insulin sensitivity in pre-frail and frail older women following a resistance training protocol. J Nutr. 2019 Jun 1;149(6):959-967. doi: 10.1093/jn/nxz038.