Breadcrumb

null Joshua Vorstenbosch, MD, PhD, FRCSC

Junior Scientist, RI-MUHC, Montreal General Hospital site

Surgical and Interventional Sciences Program

Centre for Translational Biology

Assistant Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

breast cancer reconstruction • foreign body reactions • host-implant interactions • biomaterial design • precision surgical implantation

Research Focus

My research focuses on how the body reacts to implantable non-rigid biomaterials. We use non-rigid biomaterials for a broad range of surgeries, such as breast reconstruction, hernia repair, and ocular lens replacement. While these materials are all safe, when adverse tissue reactions such as chronic inflammation or fibrosis occur at the tissue-implant interface, the implanted device becomes non-functional and patients suffer significant morbidity. To better understand why these adverse reactions happen, my lab studies the impact of various surgical and biomaterial factors on the tissue reaction at the implant interface. We are interested in using this information to develop surgical, molecular, and biomaterial solutions to improve the biocompatibility of non-rigid implants and their associated surgical outcomes.

Selected Publications

Click on Pubmed to see my current publications list

  • Surgical Management and Long-Term Outcomes of BIA-ALCL: A Multidisciplinary Approach. Vorstenbosch J, Ghione P, Plitas G, Horwitz S, Kim M, Cordeiro P, Nelson J, McCarthy C. Ann Surg Oncol. 2023 Dec 15. doi: 10.1245/s10434-023-14636-4. Online ahead of print. PMID: 38102324.

  • Implant-based breast surgery and capsular formation: when, how and why?-a narrative review. Gorgy A, Barone N, Nepon H, Dalfen J, Efanov JI, Davison P, Vorstenbosch J. Ann Transl Med. 2023 Oct 25;11(11):385. doi: 10.21037/atm-23-131. Epub 2023 Jul 6. PMID: 37970601.

  • Clinical Implications and Management of Non-BIA-ALCL Breast Implant Capsular Pathology. Vorstenbosch J, Chu JJ, Ariyan CE, McCarthy CM, Disa JJ, Nelson JA. Plast Reconstr Surg. 2023 Jan 1;151(1):20e-30e. doi: 10.1097/PRS.0000000000009780. Epub 2022 Oct 4. PMID: 36194076.

  • Axilla versus Wrist as the Recipient Site in Vascularized Lymph Node Transfer for Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis. Chocron Y, Azzi AJ, Bouhadana G, Kokosis G, Vorstenbosch J.J Reconstr Microsurg. 2022 Sep;38(7):539-548. doi: 10.1055/s-0041-1740132. Epub 2021 Dec 7. PMID: 34875698.

  • Smooth versus Textured Implant Breast Reconstruction: Patient-Reported Outcomes and Complications. Vorstenbosch J, McCarthy CM, Shamsunder MG, Polanco TO, Dabic S, Wiser I, Matros E, Dayan J, Disa JJ, Pusic AL, Cavalli MR, Encarnacion E, Lee M, Mehrara BJ, Nelson JA. Plast Reconstr Surg. 2021 Nov 1;148(5):959-967. doi: 10.1097/PRS.0000000000008411. PMID: 34705770.