null Larry Lands, MD, PhD
cystic fibrosis (CF) • primary ciliary dyskinesia (PCD) • severe asthma • lipid nanoparticles • mucus rheology • immune modulation • exercise • oscillometry • translational research
My research focuses on people, especially children, living with chronic lung diseases, such as asthma, cystic fibrosis, and primary ciliary dyskinesia, who have excessive inflammation in their lungs. This often limits their physical activity. I study how to regulate lung inflammation, boost immune defences, and improve physical performance. Clinical research is investigating the factors limiting exercise capacity in adolescents living with obesity and other at-risk populations and developing a new simpler assessment of lung function called oscillometry for infants and children. In our laboratory we are developing inhalable nucleic acid and small molecule therapies to improve cellular function, control lung inflammation, and repair damaged airways.
Dauletbaev N, Cammisano M, Herscovitch K, Lands LC. Targeted stimulation of antiviral interferon-beta in airway epithelial cells and macrophages with minimal concomitant inflammation. J Immunol 195(6):2829-41, 2015.
Dauletbaev N, Herscovitch K, Das M, Bernier J, Matouk E, Bérubé J, Rousseau S, Lands LC. Down-regulation of IL-8 in macrophages by vitamin D is individualized, requires high doses, and involves mechanisms beyond up-regulation of DUSP1. Br J Pharmacology 195(6):2829-41, 2015.
Hebestreit H, Arets HG, Aurora P, Boas S, Cerny F, Hulzebos EH, Karila C, Lands LC, Lowman JD, Swisher A, Urquhart DS; European Cystic Fibrosis Society Exercise Working Group. Statement on exercise testing in cystic fibrosis. Respiration 90(4):332-51, 2015.
Mak, DYF, Sykes J, Stephenson AL, Lands LC. The benefits of newborn screening for cystic fibrosis: The Canadian Experience. J CF 2016 May;15(3):302-8.
Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019 Nov 7;381(19):1809-1819.