Breadcrumb

null Lisbet Haglund, PhD

Senior Scientist, RI-MUHC, Montreal General Hospital site

Surgical and Interventional Sciences Program

Centre for Translational Biology

Professor, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

IVD degeneration • IVD regeneration • mechanobiology • pain • molecular markers of degeneration

Research Focus

My research focuses on characterization of molecular mechanisms leading to intervertebral disc degeneration and progression, and to develop molecular markers to follow disease state, progression or effect of treatment, and most importantly novel therapeutic interventions for degenerative and painful intervertebral disc degeneration.

Selected Publications

Click on Pubmed to see my current publications list

  • Cherif H, Bisson DG, Mannarino M, Rabau O, Ouellet JA, Haglund L. Senotherapeutic drugs for human intervertebral disc degeneration and low back pain. Elife. 2020 Aug 21;9. doi: 10.7554/eLife.54693. PMID: 32821059.

  • Fairag R, Rosenzweig DH, Ramirez-Garcialuna JL, Weber MH, Haglund L. Three-Dimensional Printed Polylactic Acid Scaffolds Promote Bone-like Matrix Deposition in Vitro. ACS Appl Mater Interfaces.2019 May 1;11(17):15306-15315. doi: 10.1021/acsami.9b02502. Epub 2019 Apr 22. PMID: 30973708.

  • Bisson DG, Sheng K, Kocabas S, Krock E, Teles A, Saran N, Ouellet JA, Haglund L. Toll-like receptor involvement in adolescent scoliotic facet joint degeneration. J Cell Mol Med. 2020 Oct;24(19):11355-11365. doi: 10.1111/jcmm.15733. Epub 2020 Aug 27. PMID: 32853438.

  • Rosenzweig DH, Fairag R, Mathieu AP, Li L, Eglin D, D'Este M, Steffen T, Weber MH, Ouellet JA, Haglund L. Thermoreversible hyaluronan-hydrogel and autologous nucleus pulposus cell delivery regenerates human intervertebral discs in an ex vivo, physiological organ culture model. Eur Cell Mater. 2018 Oct 25;36:200-217. doi: 10.22203/eCM.v036a15. PMID: 30370912.

  • Krock E, Millecamps M, Currie JB, Stone LS, Haglund L. Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model. Osteoarthritis Cartilage. 2018 Sep;26(9):1236-1246. doi: 10.1016/j.joca.2018.06.002. Epub 2018 Jun 18. PMID: 29908959.