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null Louise Larose, PhD

Honorary Investigator, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

 

Keywords

intracellular signaling • adaptor proteins • unfolded protein response • insulin resistance • obesity and diabetes

Research Focus

Louise Larose received an Honorary Investigator appointment to the Research Institute of the McGill University Health Centre in 2021, in light of her distinguished contributions as a researcher, educational administrator and mentor to countless students in the Experimental Medicine Program at McGill University. Notably, her publications represent the largest contribution of knowledge on the Nck adapter protein from any single laboratory in the world. With this focus on better understanding pancreatic beta cell failure during the development of diabetes and fat tissue behaviour during the development of obesity, her research group believes that their findings will contribute to the design of new therapeutic avenues to fight these pathological conditions in humans.

No longer accepting new graduate students.

Selected Publications

Click on Pubmed to see my current publications list

  • Haider*, N., J. Dusseault* and L. Larose. Nck1 deficiency impairs adipogenesis by activation of PDGFRα in preadipocytes. iScience 6:22-37, 2018. PMID: 30240612.

  • Kefalas, G., Jouvet, N., Baldwin, C., Estall, J. L., & Larose, L. (2018). Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses. Journal of Biological Chemistry, 293(32), 12516-12524. PMID: 29941454.

  • Kefalas* G., and L. Larose. PERK leads a hub dictating pancreatic β cell homeostasis. Biology of the Cell, 110:1-6, 2018. PMID: 29168198.

  • Li*, H., B. Li* and L. Larose. IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells. Cell Signal. 36: 79-90, 2017. PMID: 28455143.

  • Dusseault*, J., B. Li*, N. Haider*, M.-A. Goyette, J.-F, Côté and L. Larose. Nck2 deficiency in mice results in increased adiposity associated with adipocyte hypertrophy and enhanced adipogenesis. Diabetes. 65(9):2652-66, 2016. PMID: 27325288.