intracellular signaling • adaptor proteins • unfolded protein response • insulin resistance • obesity and diabetes
My research focuses on understanding molecular mechanisms involved in signal transduction regulating critical cellular functions such as embryonic development, proliferation, metabolism and response to stress. We particularly investigate the role of intracellular adaptor molecules that integrate signal transduction pathways by assembling molecular complexes involved in regulating pancreatic beta cell function and white adipose tissue biology in physiological and pathological conditions. More recently, we developed a special interest for the role of the adaptor proteins Nck in molecular mechanisms regulating the unfolded protein response in normal physiological conditions and human pathogenesis associated with impaired glucose homeostasis, and insulin production and biological actions. With this focus on better understanding pancreatic beta cell failure during the development of diabetes and fat tissue behaviour during the development of obesity, my group believes that our findings will contribute to the design of new therapeutic avenues to fight these pathological conditions in humans.
No longer accepting new graduate students.
Haider*, N., J. Dusseault* and L. Larose. Nck1 deficiency impairs adipogenesis by activation of PDGFRα in preadipocytes. iScience 6:22-37, 2018. PMID: 30240612.
Kefalas, G., Jouvet, N., Baldwin, C., Estall, J. L., & Larose, L. (2018). Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses. Journal of Biological Chemistry, 293(32), 12516-12524. PMID: 29941454.
Kefalas* G., and L. Larose. PERK leads a hub dictating pancreatic β cell homeostasis. Biology of the Cell, 110:1-6, 2018. PMID: 29168198.
Li*, H., B. Li* and L. Larose. IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells. Cell Signal. 36: 79-90, 2017. PMID: 28455143.
Dusseault*, J., B. Li*, N. Haider*, M.-A. Goyette, J.-F, Côté and L. Larose. Nck2 deficiency in mice results in increased adiposity associated with adipocyte hypertrophy and enhanced adipogenesis. Diabetes. 65(9):2652-66, 2016. PMID: 27325288.