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ovarian cancer • endometrial cancer • early detection • clinical trials • precision therapies • genomic solutions for diagnosis and treatment
I am focused on research that produces practical and immediate benefits for women with cancer. My research unit, the Women’s Health Research Unit, is active in collaborative multinational clinical trials investigating new precision therapies for gynecologic cancers. However, my main area of interest is the early detection of ovarian and uterine cancers while they are still curable. To this end, I have set up a network of satellite clinics called DOvEE (Diagnosing Ovarian and Endometrial Cancers Early), which provides open access and fast-track investigations to women over 45 with symptoms associated with gynecologic cancers. My team and I have developed a new genetic pap-test called DOvEEgene for detecting these cancers very early, before they even cause symptoms. We have completed Phase I and II testing of the DOvEEgene test and are set to launch Phase III.
Josep M. del Campo, Ursula A. Matulonis, Susanne Malander, Diane Provencher, Sven Mahner, Philippe Follana, Justin Waters, Jonathan S. Berek, Kathrine Woie, Amit M. Oza, Ulrich Canzler, Marta Gil Martin, Ann Lesoin, Bradley J Monk, Bente Lund, Lucy Gilbert, Robert M. Wenham, Benedict Benigno, Sujata Arora, Sebastien J. Hazard, Mansoor R. Mirza, Niraparib Maintenance Therapy in Patients With Recurrent Ovarian Cancer Following a Partial Response to the Last Platinum-Based Chemotherapy in the ENGOT-OV16/NOVA Trial, Journal of Clinical Oncology 37 (32): 2968-2977), Jun 7, 2019 DOI: 10.1200/JCO.18.02238.
Yuxuan Wang, Lu Li, Christopher Douville, Joshua D. Cohen, Isaac Kinde, Karin Sundfelt, Susanne Krüger Kjær, Ie-Ming Shih, Tian-Li Wang, Robert Kurman, Simeon Springer, Janine Ptak, Maria Popoli, Joy Schaefer, Natalie Silliman, Lisa Dobbyn, Ting-Tai Yen, Maria Lycke, Kirsten Jochumsen, Bahman Afsari, Douglas Levine, Kris Jardon, Xing Zeng, Jocelyne Arseneau Lili Fu, Luis A. Diaz Jr., Rachel Karchin, Cristian Tomasetti, Kenneth W. Kinzler, Bert Vogelstein, Amanda N. Fader, *Lucy Gilbert, Nick Papadopoulos. Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers, 21 March 2018, Sci. Transl. Med. 10, DOI: 10.1126/scitranslmed.aap8793, *corresponding author
Gilbert L, Revil T, Meunier C, Jardon K, Zeng X , Martins C, Arseneau J, Fu L, North K, Schiavi A, Ehrensperger E, Artho G, Todd L, Morris D, Ragoussis J. The Empress of Subterfuge: cancer of the fallopian tube presenting with malapropism. The Lancet, Sep 2017; 390 (10098):1003-1004.
Mansoor R. Mirza, Bradley J. Monk, Jørn Herrstedt, Amit M. Oza, Sven Mahner, Andrés Redondo, Michel Fabbro, Jonathan A. Ledermann, Domenica Lorusso, Ignace Vergote, Noa Efrat Ben-Baruch, Christian Marth, Radosław Mądry, René dePont Christensen, Jonathan S. Berek, Anne Dørum, Anna V. Tinker, Andreas du Bois, Antonio González Martín, Philippe Follana, Benedict Benigno, Per Rosenberg, Lucy Gilbert, Bobbie J. Rimel, Joseph Buscema, John P. Balser, Shefali Agarwal, Ursula A. Matulonis. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer, New England Journal of Medicine, October 2016, 375(22): 2154-2164. DOI: 10.1056/NEJMoa1611310.
Gilbert L, Basso O, Sampalis J, Karp I, Martins C, Feng J, Piedimonte S, Quintal L, Ramana-Kumar AV, Takefman J, Grigorie MS, Artho G, Krishnamurthy S, for the DOvE Study Group. Assessment of symptomatic women for early diagnosis of ovarian cancer: results from the prospective DOvE pilot project. Lancet Oncol. March 2012; 13(3): 285-91. PMID: 22257524.