My research focuses on the early detection of ovarian cancer, research into new drug treatments for ovarian and uterine cancers, improving outcomes following the surgical treatment of gynecological cancers and fertility preservation in women with cancers. One of the seminal research projects initiated at the MUHC is the DOVE (Detecting OVarian cancer Earlier) project. This ambitious endeavour, which is funded by the CIHR and various cancer foundations, aims to detect ovarian cancer earlier thanks to a clinical approach that uses a prevalence function for triaging symptomatic patients, and a basic science component aimed at developing better biomarkers.
Gilbert L, Basso O, Sampalis J, Karp I, Martins C, Feng J, Piedimonte S, Quintal L, Ramana-Kumar AV, Takefman J, Grigorie MS, Artho G, Krishnamurthy S; for the DOvE Study Group. Assessment of symptomatic women for early diagnosis of ovarian cancer: results from the prospective DOvE pilot project. Lancet Oncol. 2012 Mar;13(3) : 285-91.PubMed PMID: 22257524
Lachapelle J, Gilbert L, Artho G, Alcindor T, Amre R, Arseneau J and Foulkes W. Colonic or coelomic? The Lancet, 2010; 375(9728):1844.
Bell-McGuinn KM, Matthews CM, Ho SN, Barve M, Gilbert L, Penson RT, Lengyel E, Palaparthy R, Gilder K, Vassos A, McAuliffe W, Weymer S, Barton J, Schilder RJ. A phase II, single-arm study of the anti-α5&beta1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecol Oncol. 2011 May 1;121(2):273-9
Rio Frio T, Bahubeshi A, Kanellopoulou C, Hamel N, Niedziela M, Sabbaghian N, Pouchet C, Gilbert L, O'Brien PK, Serfas K, Broderick P, Houlston RS, Lesueur F, Bonora E, Muljo S, Schimke RN, Bouron-Dal Soglio D, Arseneau J, Schultz KA,Priest JR, Nguyen VH, Harach HR, Livingston DM, Foulkes WD, Tischkowitz M. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydigcell tumors. JAMA. 2011 Jan 5;305(1):68-77