null Marco Leyton, PhD

Senior Scientist, RI-MUHC

Brain Repair and Integrative Neuroscience (BRaIN) Program

Professor, Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University



substance use disorders • personality disorders • mood disorders • impulsivity • PET • MRI • vulnerability

Research Focus

My research focuses on the causes of addictions and addiction-related disorders. By using state-of-the-art biopsychosocial research strategies, we have identified individual differences that predict differential susceptibility to mental health problems and potential targets for treatment.

Selected Publications

Click on Pubmed to see my current publications list

  • Iqbal M, Cox SML, Jaworska N, Tippler M, Castellanos-Ryan N, Parent S, Dagher A, Vitaro F, Brendgen M, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M. A three-factor model of common early onset psychiatric disorders: temperament, adversity, and dopamine. Neuropsychopharmacology 2022. PMID: 34625707.

  • Cox SML, Castellanos-Ryan N, Parent S, Benkelfat C, Vitaro F, Pihl RO, Boivin M, Tremblay R, Leyton M, Seguin J. Externalizing risk pathways for substance use problems. Canadian Journal of Psychiatry 2021. PMID: 33530707.

  • Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M. Extra-striatal dopamine2/3 receptor availability in youth at-risk for addictions. Neuropsychopharmacology 2020. PMID: 32259831.

  • Vosberg D, Leyton M, Flores C. The netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence. Molecular Psychiatry 2020;25(2):297-307. PMID: 31659271.

  • Leyton M, Vezina P. Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model. Trends in Pharmacological Sciences 2014;35(6):268-276. PMID: 24794705.