sleep-disordered breathing • fatigue • cognition • neurological disorders • noninvasive ventilation
My research focuses on respiratory issues in neurological diseases, particularly sleep-related breathing disorders such as obstructive sleep apnea (OSA). It is divided in two themes. In theme 1, I study the interaction between OSA and central nervous system disorders, such as multiple sclerosis and Parkinson's disease. On the one hand, neurological disorders may lead to OSA. On the other, treating OSA may help specific symptoms and quality of life in those patients. Theme 2 relates to various aspects of respiratory care of patients with neuromuscular diseases (which cause muscle weakness). Amyotrophic lateral sclerosis (ALS) is such a disease, causing progressive weakening of respiratory muscles leading to respiratory failure. I have been studying the measurement of respiratory strength, lung volume recruitment manoeuvres (a technique that helps maintain lung health), and new modes of adjusting a ventilator for long term use at home.
Kaminska M, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Gros P, Kimoff RJ. Change in Cognition and Other Non-Motor Symptoms With Obstructive Sleep Apnea Treatment in Parkinson Disease. J Clin Sleep Med. 2018 May 15;14(5):819-828. doi: 10.5664/jcsm.7114. PMID: 29734988.
Kaminska M, Noel F, Petrof BJ. Optimal method for assessment of respiratory muscle strength in neuromuscular disorders using sniff nasal inspiratory pressure (SNIP). PLoS One. 2017 May 16;12(5):e0177723. doi: 10.1371/journal.pone.0177723. PMID: 28520769.
Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. 2017 Mar 21;88(12):1120-1128. doi: 10.1212/WNL.0000000000003738. Epub 2017 Feb 22. PMID: 28228566.
Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime. Sleep Breath. 2016 Mar;20(1):205-12. doi: 10.1007/s11325-015-1208-9. Epub 2015 Jun 13. PMID: 26070532.
Kaminska M, Lafontaine AL, Kimoff RJ. The Interaction between Obstructive Sleep Apnea and Parkinson's Disease: Possible Mechanisms and Implications for Cognitive Function. Parkinsons Dis. 2015;2015:849472. doi: 10.1155/2015/849472. Epub 2015 Oct 5. Review. PMID: 26509097.