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My research focuses on head and neck cancer and in particular on development of novel therapeutic strategies for oral and throat cancer. I focus on harnessing advances in systemic therapies and minimally invasive robotic surgery to develop novel combinations allowing effective cancer control and minimizing chronic therapy-related toxicity. Through adaptive clinical trials starting with systemic therapy, I am investigating a personalized adaptive approach for surgical treatment of oral and throat cancer. I am investigating molecular determinants of cancer response to chemotherapy to help design personalized treatment with a focus on cancer cure while preserving quality of life and functional outcome after cancer treatment.
Sadeghi N, Li NW, Taheri MR, Easley S, Siegel RS. Neoadjuvant chemotherapy and transoral surgery as a definitive treatment for oropharyngeal cancer: A feasible novel approach. Head Neck. 2016. PMID: 27299983.
Sadeghi N, Li NW, Shokri T, Akin E, Joshi AS, Knoll S. Minimally elevated preoperative parathyroid hormone level influences the management of primary hyperparathyroidism. Laryngoscope. 2017. PMID: 28850730.
Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, et al. American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA Cancer J Clin. 2016. PMID: 27002678.
Mai JP, Sadeghi N. Pharyngeal Tube Flap and Palatoglossal Rotation Flap in Subtotal Soft Palate Reconstruction. Otolaryngol Head Neck Surg. 2015. PMID: 26354028.
Peng J, Feng Y, Rinaldi G, Levine P, Easley S, Martinez E, et al. Profiling miRNAs in nasopharyngeal carcinoma FFPE tissue by microarray and Next Generation Sequencing. Genomics Data. 2014;2(0):285-9. PMID: 26484110.