Research Focus

My research focuses on head and neck cancer and in particular on development of novel therapeutic strategies for oral and throat cancer. I focus on harnessing advances in systemic therapies and minimally invasive robotic surgery to develop novel combinations allowing effective cancer control and minimizing chronic therapy-related toxicity. Through adaptive clinical trials starting with systemic therapy, I am investigating a personalized adaptive approach for surgical treatment of oral and throat cancer. I am investigating molecular determinants of cancer response to chemotherapy to help design personalized treatment with a focus on cancer cure while preserving quality of life and functional outcome after cancer treatment.

Selected Publications

• Sadeghi N, Li NW, Taheri MR, Easley S, Siegel RS. Neoadjuvant chemotherapy and transoral surgery as a definitive treatment for oropharyngeal cancer: A feasible novel approach. Head Neck. 2016. PMID: 27299983.

• Sadeghi N, Li NW, Shokri T, Akin E, Joshi AS, Knoll S. Minimally elevated preoperative parathyroid hormone level influences the management of primary hyperparathyroidism. Laryngoscope. 2017. PMID: 28850730.

• Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA, et al. American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA Cancer J Clin. 2016. PMID: 27002678.

• Mai JP, Sadeghi N. Pharyngeal Tube Flap and Palatoglossal Rotation Flap in Subtotal Soft Palate Reconstruction. Otolaryngol Head Neck Surg. 2015. PMID: 26354028.

• Peng J, Feng Y, Rinaldi G, Levine P, Easley S, Martinez E, et al. Profiling miRNAs in nasopharyngeal carcinoma FFPE tissue by microarray and Next Generation Sequencing. Genomics Data. 2014;2(0):285-9. PMID: 26484110.