HIV/AIDS • cellular Immunology • correlates of protection • T cells • NK cells
My research focuses on why some people who are exposed to HIV multiple times do not become infected. I am also interested in understanding why a small subset of HIV infected people control their HIV infection without treatment and exhibit very slow HIV disease progression. We have found evidence that Natural Killer cells play a role in protection from infection and slow time to AIDS in those infected. One of our research goals is to understand the mechanisms underlying these favorable responses to HIV.
Boulet, S, R Song, P Kamya, J Bruneau, NH Shoukry, CM Tsoukas and NF Bernard. HIV protective KIR3DL1-HLA-B combined genotypes influence natural killer cell function following stimulation with HLA-devoid cells. J Immunol 184:2057-64, 2010 PMID: 20061407.
Kamya P, S Boulet, CM Tsoukas, J-P Routy, R Thomas, P Côté, M-R Boulassel, J-G Baril, C Kovacs, SA Migueles, M Connors, T J Suscovich, C Brander, CL Tremblay, N F Bernard for the Canadian Cohort of HIV Infected Slow Progressors. Receptor-ligand requirements for increased NK cell poly-functional potential in *h/*y+B57 HIV-1 infected Slow progressors. J Virol. 85: 5949, 2011. PMCID: PMC3126301.
Kamya P, B Tallon, C Melendez-Pena, SA Migueles, M Connors, CL Tremblay and NF Bernard for the Canadian Cohort of HIV Infected Slow Progressors. Inhibitory Killer Immunoglobulin-like Receptors to self HLA-B and HLA-C ligands contribute differentially to Natural Killer cell functional potential in HIV infected slow progressors. Clin Immunol 143:246-55, 2012 PMID: 22445844.
Parsons, MS, RJ Center, J-P Routy, D Rouleau, R LeBlanc, MA Wainberg, CL Tremblay, MD Zannou, SJ Kent, MD Grant and NF Bernard. Antibody responses to human immunodeficiency virus Envelope from infections with multiple viral types and subtypes utilize the 1F7-idiotypic repertoire. AIDS Research Human Retroviruses. 29:778-83, 2013. PMCID: PMC3636582.
Song R, I Lisovsky, B Lebouché, J-P Routy, J Bruneau and NF Bernard. HIV Protective KIR3DL1/HLA-B Genotypes Influence NK Cell Mediated Inhibition of HIV Replication in Autologous CD4 T Cell Targets. PloS Pathogens ePub 16 January 2014 PMCID: PMC3894215.