null Nicole Bernard, PhD
HIV/AIDS • immunology • virology • host responses to HIV • NK cells • NK cell receptors • T cells
My research program aims to inform the development of protective HIV vaccines and understand how to achieve a functional HIV cure. One of my CIHR-funded research projects focuses on the mechanisms that underlie resistance to HIV infection and viral control without treatment in a rare subset of HIV-infected elite controllers. A second studies the mechanisms underlying protection from HIV infection in persons who remain HIV-seronegative despite multiple exposures to HIV. As adjunct director of the FRQ-S─funded AIDS and Infectious Diseases Network since 2018, I oversee the Network’s HLA typing core and am the co-principal investigator of the Canadian Cohort of HIV Infected Slow Progressors.
Dupuy, FP, S Kant, Al Barbé, J-P Routy, J Bruneau, B Lebouché, C Tremblay, M Pazgier, A Finzi and NF Bernard. Antibody-dependent cellular cytotoxicity-competent ADCC competent antibodies against HIV-1-infected cells in plasma from HIV-infected subjects. mBio 17;10(6). pii: e02690-19. doi: 10.1128/mBio.02690-19. PMID: 31848282.
Kiani Z, Franck P Dupuy, J Bruneau, B Lebouché, C Retière, DE Geraghty and NF Bernard. The education of NK cells determines their responsiveness to autologous HIV-infected CD4 T cells. J Virol 2019 Nov 13;93(23). pii: e01185-19. doi: 10.1128/JVI.01185-19. Print 2019 Dec 1. PMID: 31511383.
Kiani, Z, J Bruneau, DE Geraghty and NF Bernard. HLA-F on autologous HIV-infected cells activated primary NK cells expressing the activating NK cell receptor KIR3DS1. J Virol. 2019 Aug 28;93(18). pii: e00933-19. doi: 10.1128/JVI.00933-19. Print 2019 Sep 15. PMID: 31270222.
Kant S, N Zhang, JP Routy, C Tremblay, R Thomas, J Szabo, P Côté, B Trottier, R LeBlanc, D Rouleau, M Harris, FP Dupuy and NF Bernard NF. Quantifying anti-HIV envelope-specific antibodies in plasma from HIV infected individuals. Viruses. 2019 May 28;11(6). pii: E487. doi: 10.3390/v11060487. PMID: 31141927.
Lisovsky I, A Tremblay-McLean, G Isitman, NH Shoukry, MA. Wainberg, J Bruneau and NF Bernard. Divergent contributions of NK cell education through KIR2DL1, KIR2DL3 and KIR3DL1 to anti-HIV antibody-dependent cellular cytotoxicity and antibody-dependent NK cell activation. J Leukoc Biol. 2019 Mar;105(3):551-563. doi: 10.1002/JLB.4A0617-242RRR. Epub 2019 Jan 30. PMID: 30698860.