Breadcrumb

null Nicole Bernard, PhD

Scientist, RI-MUHC, Glen site

Infectious Diseases and Immunity in Global Health Program

Centre for Translational Biology

Associate Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Allergy & Immunology, MUHC

 

Keywords

HIV/AIDS • immunology • virology • host responses to HIV • NK cells • NK cell receptors • T cells

Research Focus

My research program aims to inform the development of protective HIV vaccines and understand how to achieve a functional HIV cure. One of my CIHR-funded research projects focuses on the mechanisms that underlie resistance to HIV infection and viral control without treatment in a rare subset of HIV-infected elite controllers. A second studies the mechanisms underlying protection from HIV infection in persons who remain HIV-seronegative despite multiple exposures to HIV. As adjunct director of the FRQ-S─funded AIDS and Infectious Diseases Network since 2018, I oversee the Network’s HLA typing core and am the co-principal investigator of the Canadian Cohort of HIV Infected Slow Progressors.

Selected Publications

Click on Pubmed to see my current publications list

  • Dupuy, FP, S Kant, Al Barbé, J-P Routy, J Bruneau, B Lebouché, C Tremblay, M Pazgier, A Finzi and NF Bernard. Antibody-dependent cellular cytotoxicity-competent ADCC competent antibodies against HIV-1-infected cells in plasma from HIV-infected subjects. mBio 17;10(6). pii: e02690-19. doi: 10.1128/mBio.02690-19. PMID: 31848282.

  • Kiani Z, Franck P Dupuy, J Bruneau, B Lebouché, C Retière, DE Geraghty and NF Bernard. The education of NK cells determines their responsiveness to autologous HIV-infected CD4 T cells. J Virol 2019 Nov 13;93(23). pii: e01185-19. doi: 10.1128/JVI.01185-19. Print 2019 Dec 1. PMID: 31511383.

  • Kiani, Z, J Bruneau, DE Geraghty and NF Bernard. HLA-F on autologous HIV-infected cells activated primary NK cells expressing the activating NK cell receptor KIR3DS1. J Virol. 2019 Aug 28;93(18). pii: e00933-19. doi: 10.1128/JVI.00933-19. Print 2019 Sep 15. PMID: 31270222.

  • Kant S, N Zhang, JP Routy, C Tremblay, R Thomas, J Szabo, P Côté, B Trottier, R LeBlanc, D Rouleau, M Harris, FP Dupuy and NF Bernard NF. Quantifying anti-HIV envelope-specific antibodies in plasma from HIV infected individuals. Viruses. 2019 May 28;11(6). pii: E487. doi: 10.3390/v11060487. PMID: 31141927.

  • Lisovsky I, A Tremblay-McLean, G Isitman, NH Shoukry, MA. Wainberg, J Bruneau and NF Bernard. Divergent contributions of NK cell education through KIR2DL1, KIR2DL3 and KIR3DL1 to anti-HIV antibody-dependent cellular cytotoxicity and antibody-dependent NK cell activation. J Leukoc Biol. 2019 Mar;105(3):551-563. doi: 10.1002/JLB.4A0617-242RRR. Epub 2019 Jan 30. PMID: 30698860.