null Paul Sabatini, PhD

Junior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Assistant Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University



central nervous system • feeding behaviour • energy expenditure • obesity brainstem • hypothalamus

Research Focus

My research focuses on identifying and studying cell types across the central nervous system that regulate feeding behaviour or energy expenditures. Additionally, I develop new tools to facilitate the study of these cells. The ultimate goal of my research is to better understand how the brain regulates energy balance and how to leverage this information to treat diseases such as obesity.

Selected Publications

Click on Pubmed to see my current publications list

  • Affinati AH, Sabatini PV, True C, Tomlinson AJ, Kirigiti M, Lindsley SR, Li C, Olson DP, Kievit P, Myers MG Jr, Rupp AC. Cross-Species analysis defines the conservation of anatomically-segregated VMH neuron populations. Elife. 2021 May 21;10:e69065. doi: 10.7554/eLife.69065. Epub ahead of print. PMID: 34018926.

  • Sabatini PV, Wang J, Rupp AC, Affinati AH, Flak JN, Li C, Olson DP, Myers MG. tTARGIT AAVs mediate the sensitive and flexible manipulation of intersectional neuronal populations in mice. Elife. 2021 Mar 11;10:e66835. doi: 10.7554/eLife.66835. PMID: 33704065.

  • Sabatini PV, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp AC, Adams JM, Wang J, Beck Jørgensen S, Olson DP, Palmiter RD, Myers MG Jr, Seeley RJ. GFRAL-expressing neurons suppress food intake via aversive pathways. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118. doi: 10.1073/pnas.2021357118. PMID: 33593916.

  • Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG Jr. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 Jun 1;130(6):2943-2952. doi: 10.1172/JCI134135. PMID: 32134398.

  • Barnes TM, Shah K, Allison MB, Steinl GK, Gordian D, Sabatini PV, Tomlinson AJ, Cheng W, Jones JC, Zhu Q, Faber C, Myers MG Jr. Identification of the leptin receptor sequences crucial for the STAT3-Independent control of metabolism. Mol Metab. 2020 Feb;32:168-175. doi: 10.1016/j.molmet.2019.12.013. Epub 2020 Jan 3. PMID: 32029227.