null Per Jesper Sjöström, M.Sc., PhD
synaptic plasticity • learning and memory • neuronal circuits • synaptic disease
My research focuses on understanding the functioning of the brain, by elucidating the properties and the mechanistic underpinnings of plasticity, as well as its functional impact. In addition, we investigate the connectivity patterns that ensue from plasticity and how these are shaped by activity. Our goal is to understand the role of plasticity in health as well as in pathologies such as epilepsy and autism. To do this, my team employs state-of-the-art technology such as quadruple whole-cell recordings, two-photon laser scanning microscopy, and computer simulations.
Watanabe A, Guo C, Sjöström PJ: The Developmental Profile of Visual Cortex Astrocytes.iScience (2023) doi: 10.1016/j.isci.2023.106828. PMID: 37250801.
McFarlan AR, Chou CYC, Watanabe A, Cherepacha N, Haddad M, Owens H, & Sjöström PJ: The plasticitome of cortical interneurons. Nature Reviews Neuroscience (2023) doi: 10.1038/s41583-022-00663-9. PMID: 36585520.
Mizusaki BEP, Li SSY, Costa RP, and Sjöström PJ: Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning. PLoS Computational Biology (2022) 18, e1009409. 10.1371/journal.pcbi.1009409. PMID: 35700188.
Cela E, McFarlan AR, Chung AJ, Wang T, Chierzi S, Murai KK, & Sjöström PJ: An Optogenetic Kindling Model of Neocortical Epilepsy. Scientific Reports (2019) 9:5236. DOI: 10.1038/s41598-019-41533-2. PMID: 30918286.
Dore K, Stein IS, Brock JA, Castillo PE, Zito K, & Sjöström PJ: Unconventional NMDA Receptor Signaling. The Journal of Neuroscience (2017) 37(45):10800-10807. DOI: 10.1523/JNEUROSCI.1825-17.2017. PMID: 29118208.