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angle-left Pierre Lachapelle, PhD

Senior Scientist, RI-MUHC, Glen site

Child Health and Human Development Program

Centre for Translational Biology

Professor, Department of Ophthalmology, Faculty of Medicine, McGill University

 

Keywords


ophthalmology • electroretinography • electrophysiology • development • retinopathy

Research Focus


My research focuses on developing models (human and animal) aimed at improving our understanding of normal and pathological visual function, from the retina to the visual cortex. My laboratory is also involved in characterizing animal models of human retinal diseases such as retinopathy of prematurity, age-related macular degeneration, and retinitis pigmentosa, for example, with the goal of further elucidating the pathogenesis of these retinopathies and exploring new therapeutic strategies with which to eradicate them.

Selected Publications


  • Vatcher D, Dorfman AL, Shen Y, You JY, Sun V, Khan A, Polomeno RC, Lachapelle P (2019). Revealing a retinal facilitatory effect with the multifocal ERG. Doc Ophthalmol. 138(2):117-124.

  • Polosa A, Bessaklia H, Lachapelle P (2017). Light-Induced Retinopathy: Young Age Protects more than Ocular Pigmentation. Curr Eye Res. 42(6):924-935.

  • Gauvin M, Sustar M, Little JM, Brecelj J, Lina JM, Lachapelle P (2017). Quantifying the ON and OFF Contributions to the Flash ERG with the Discrete Wavelet Transform. Transl Vis Sci Technol. 10;6(1):3. doi: 10.1167/tvst.6.1.3. eCollection 2017 Jan.

  • Gauvin M, Chakor H, Koenekoop RK, Little JM, Lina JM, Lachapelle P (2016). Witnessing the first sign of retinitis pigmentosa onset in the allegedly normal eye of a case of unilateral RP: a 30-year follow-up. Doc Ophthalmol. 132:213-29.

  • Polosa A, Liu W, Lachapelle P. (2016). Retinotopic Distribution of Structural and Functional Damages following Bright Light Exposure of Juvenile Rats. PLoS One. 19;11(1):e0146979. doi: 10.1371/journal.pone.0146979. eCollection 2016.