Breadcrumb

null Richard Kremer, MD, PhD

Senior Scientist, RI-MUHC , Glen site

Metabolic Disorders and Complications Program

Centre for Translational Biology

Professor, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University

Department of Medicine, Division of Biochemistry, MUHC

 

Keywords

Vitamin D • Parathyroid hormone related peptide (PTHrP) • Breast cancer • skeletal metastasis • circulating tumor cells • genetically engineered mouse models • tumor progression • metabolic bone disorders • translational studies

Research Focus

My research focuses on the role of calcium-regulating hormones in health and disease. My laboratory aims to elucidate how 1,25-dihydroxyvitamin D3, the active form of vitamin D, influences cell growth and differentiation in the skeleton and in cancer cells, and to elaborate new therapeutic strategies with vitamin D derivatives in osteoporosis and cancer. Another major focus of my research activities has been to establish the role of parathyroid hormone-related protein (PTHrP) in tumour initiation, growth and metastasis. This work has led to the development of a novel targeted therapy against breast cancer using monoclonal antibodies raised against PTHrP.

Selected Publications

Click on Pubmed to see my current publications list

  • Solomon C, White JH, Kremer R. Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest. 1999 Jun;103(12):1729-35. PMID: 10377179.

  • El Abdaimi K, Dion N, Papavasiliou V, Cardinal PE, Binderup L, Goltzman D, Ste-Marie LG, Kremer R. The vitamin D analogue EB 1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Res. 2000 Aug 15;60(16):4412-8. PMID: 10969786.

  • Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009 Jan;94(1):67-73. doi: 10.1210/jc.2008-1575. Epub 2008 Nov 4. PMID: 18984659.

  • Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest. 2011 Dec;121(12):4655-69. doi: 10.1172/JCI46134. Epub 2011 Nov 7. PMID: 22056386.

  • Kremer R, Gagnon B, Meguerditchian AN, Nadeau L, Mayo N. Effect of oral bisphosphonates for osteoporosis on development of skeletal metastases in women with breast cancer: results from a pharmaco-epidemiological study. J Natl Cancer Inst. 2014 Oct 2;106(11). pii: dju264. doi: 10.1093/jnci/dju264. Print 2014 Nov. PMID: 25278509.