null Richard Kremer, MD, PhD
Vitamin D • Parathyroid hormone related peptide (PTHrP) • Breast cancer • skeletal metastasis • circulating tumor cells • genetically engineered mouse models • tumor progression • metabolic bone disorders • translational studies
My research focuses on the role of calcium-regulating hormones in health and disease. My laboratory aims to elucidate how 1,25-dihydroxyvitamin D3, the active form of vitamin D, influences cell growth and differentiation in the skeleton and in cancer cells, and to elaborate new therapeutic strategies with vitamin D derivatives in osteoporosis and cancer. Another major focus of my research activities has been to establish the role of parathyroid hormone-related protein (PTHrP) in tumour initiation, growth and metastasis. This work has led to the development of a novel targeted therapy against breast cancer using monoclonal antibodies raised against PTHrP.
Solomon C, White JH, Kremer R. Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha. J Clin Invest. 1999 Jun;103(12):1729-35. PMID: 10377179.
El Abdaimi K, Dion N, Papavasiliou V, Cardinal PE, Binderup L, Goltzman D, Ste-Marie LG, Kremer R. The vitamin D analogue EB 1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Res. 2000 Aug 15;60(16):4412-8. PMID: 10969786.
Kremer R, Campbell PP, Reinhardt T, Gilsanz V. Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab. 2009 Jan;94(1):67-73. doi: 10.1210/jc.2008-1575. Epub 2008 Nov 4. PMID: 18984659.
Li J, Karaplis AC, Huang DC, Siegel PM, Camirand A, Yang XF, Muller WJ, Kremer R. PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest. 2011 Dec;121(12):4655-69. doi: 10.1172/JCI46134. Epub 2011 Nov 7. PMID: 22056386.
Kremer R, Gagnon B, Meguerditchian AN, Nadeau L, Mayo N. Effect of oral bisphosphonates for osteoporosis on development of skeletal metastases in women with breast cancer: results from a pharmaco-epidemiological study. J Natl Cancer Inst. 2014 Oct 2;106(11). pii: dju264. doi: 10.1093/jnci/dju264. Print 2014 Nov. PMID: 25278509.