genetics • type 2 diabetes • obesity
My research focuses on learning how genetic mutations cause diabetes and other complex diseases. To do this, my group has developed new approaches to identify genetic changes across the whole human genome that are associated with type 2 diabetes, and also to identify the effects of genetic variation on RNA splicing and gene activation in mouse strains and human populations. Current projects in the lab center on developing new experimental techniques to learn how genetic changes within individual genes and proteins can impair cell metabolism and cause diabetes. Reflecting the increasing impact of diabetes and obesity on global health, much of the group's research in the genetics of diabetes takes place as part of research teams that involve scientists in America, Europe and Asia.
M. Mancini, G. Caignard, B. Charbonneau, A. Dumaine, N. Wu, G.A. Leiva-Torres, S. Gerondakis, A. Pearson, S.T. Qureshi, R. Sladek and S.M. Vidal. Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. J Immunology. 202:1479-1493. 1 March 2019. PMID: 30683700.
R. Dali, F. Verginelli, A. Pramatarova, R. Sladek and S. Stifani. Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma initiating cells. Molecular Oncology. 12:775-787. June 2018. PMID: 29316219.
R. Sladek. The many faces of diabetes: addressing heterogeneity of a complex disease. Lancet Diabetes & Endocrinology. 6: 348-349. May 2018. PMID: 29503171.
G. Jun, A. Manning, M. Almeida, M. Zawistowski, A.R. Wood, T.M. Teslovich, C. Fuchsberger, S. Feng, P. Cingolani, … 57 authors … R. Sladek, D. Altshuler, M.I. McCarthy, R. Duggirala, M. Boehnke, T.M. Frayling, G.R. Abecasis and J. Blangero. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proceedings of the National Academy of Science USA. 115:379-384. 9 January 2018. PMID: 29279374.
E. Wheeler, A. Leong, C.T. Liu, M.-F. Hivert, R. J. Strawbridge, ... 202 authors ... J.C. Florez, R. Sladek, J. Dupuis, A.P. Morris, E.S. Tai, E. Selvin, J.I. Rotter, C. Langenberg, I. Barroso and J.B. Meigs. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis PLoS Medicine. 14(9):e1002383. 12 Sept 2017. PMID: 28898252.