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breast cancer • prognosis • pathogenesis • diagnosis
My research focuses on the diagnosis, pathogenesis and prognosis of breast cancer. I am interested in finding newer and better modalities for the diagnosis of breast cancer. I would also like to better understand how a normal breast ductal epithelial cell becomes malignant. Along with many researchers, we are looking at normal and atypical duct cells grown in 3D culture to elucidate the initial steps in carcinogenesis, and we are dissecting the molecular mechanisms of breast cancer progression to identify markers in the blood that can predict the presence of a breast cancer. In addition, by using gene arrays we are trying to identify gene signatures that predict better response to chemotherapy and can identify patients with aggressive tumors despite favorable pathologies.
Pepin F, Bertos N, Laferriere J, Sadekova S, Souleimanova M, Zhao H, Finak G, Meterissian S, Hallett M and Park M 2012 Gene expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes Breast Cancer Research 14(4):R120 PMID: 22906178.
Cools-Lartigue J., Sinclair A., Trabulsi N., Meguerditchian A., Mesurolle B., Fuhrer R. and Meterissian S. 2013 Preoperative axillary ultrasound and fine-needle aspiration biopsy in the diagnosis of axillary metastases in patients with breast cancer: predictors of accuracy and future implications. Ann. Surg. Oncol. 20:819-827. PMID: 22972506.
Zheng J., Alsaadi T., Blaichman J., Xie X., Omeroglu A., Meterissian S. and Mesurolle B. 2013 Invasive ductal carcinoma of the breast: correlation between tumor grade determined by ultrasound-guided core biopsy and surgical pathology American J. Roentgenol. 200: W71-74 PMID: 23255773.
Parsyan A., Mesurolle B and Meterissian S. 2013 Impact of preoperative breast MRI on surgical decision-making and clinical outcomes: a systematic review World Journal of Surgery 37:2134-2139 PMID: 23661259.
Meterissian S. 2014 Atypical ductal hyperplasia diagnosed at sonographically guided core needle biopsy: frequency, final surgical oucome and factors associated with underestimation. Am. J. Roentgenol. 202: 1389-1394 PMID: 24848840.